Clinical trials and the acceptance of uncertainty

Bracken, Michael B.
May 1987
British Medical Journal (Clinical Research Edition);5/2/1987, Vol. 294 Issue 6580, p1111
Academic Journal
Examines dispensability of clinical trials and acceptance of uncertainty in medical practice. Importance of Lugano report on highlighting problems affecting attitude toward clinical trials; Concern om randomized clinical trial violating doctor-patient relationship; Perception on dilemma on balancing unnecessary risk of current patient against risk of future patients.


Related Articles

  • The CONSORT Patient-Reported Outcome (PRO) extension: implications for clinical trials and practice. Calvert, Melanie; Brundage, Michael; Jacobsen, Paul B.; Sch√ľnemann, Holger J.; Efficace, Fabio // Health & Quality of Life Outcomes;2013, Vol. 11 Issue 1, p1 

    To inform clinical guidelines and patient care we need high quality evidence on the relative benefits and harms of intervention. Patient reported outcome (PRO) data from clinical trials can "empower patients to make decisions based on their values" and "level the playing field between physician...

  • Recruitment Rates and Data Quality. Platonov, Pyotr G.; Escandon, Rafael; Varshavsky, Sergei // Applied Clinical Trials;Nov2003, Vol. 12 Issue 11, p32 

    No abstract available.

  • Trial Site Insight: Will Your Trial Master File Pass FDA Inspection?  // BioWorld Insight;1/25/2010, Vol. 18 Issue 4, p2 

    The article reports on the warning letters sent by the Center for Drug Evaluation and Research (CDER) to trial for good clinical practice in the U.S.

  • How we took the pain out of patient complaints. Butt, Sohail // Pulse;9/22/2003, Vol. 63 Issue 38, p46 

    Presents strategies to improve handling of patient complaints in Great Britain. Application of practice-based procedure for dealing with complaints; Overview of the national criteria; Development of practical steps to alleviate patient's condition.

  • Do treatment protocols improve end results? A study of survival of patients with multiple myeloma in Finland. Karjalainen, Sakari; Palva, Ilmari // BMJ: British Medical Journal (International Edition);10/28/89, Vol. 299 Issue 6707, p1069 

    Examines the survival of patients with multiple myeloma in Finland. Principles of clinical practice; Types of treatment protocols included in clinical trials; Effect of sex, time of diagnosis and area of residence as prognostic factors on the relative survival.

  • Practice guideline authors keep ties to industry quiet. Freedman, Marian // Contemporary Pediatrics;Mar2002, Vol. 19 Issue 3, p13 

    Suggests that pediatricians may be concerned about the results of a survey that reveals that six of 10 practice guideline authors scrutinized by investigators had a financial tie to a manufacturer whose drugs were considered or recommended in the guidelines they developed. Number of children...

  • Evidently. Lehman, Richard // Evidence Based Medicine;Oct2005, Vol. 10 Issue 5, p135 

    The article presents information related to medical research. Randomized controlled trials and systematic reviews are all very well, but in medical practice practitioners are often trying to modify ingrained patient behaviors over a series of encounters. Some would argue that even acupuncture is...

  • Considerations on the Impact of Direct-to-Patient Contacts. Fournie, Xavier; Siebenaler, Jean; Wiederkehr, Sandra // Applied Clinical Trials;Dec2016/Jan2017, Vol. 25 Issue 12, p38 

    The article offers information on new clinical trials regulation on medicinal products for human use repealed clinical trials by European Parliament and the Council on clinical trials. Topics discussed include diagnosis or monitoring procedures for clinical practice, new subtype of clinical...

  • Rhyme and reason: Searching for poems in medical practice. Maurer, Brian T. // JAAPA: Journal of the American Academy of Physician Assistants (;Aug2009, Vol. 22 Issue 8, p60 

    The article presents the author's views concerning the definition of the word POEMS that appeared on a medical journal. According to him, it was his first encounter of the word POEMS in a medical journal which simply means patient-oriented evidence that matters. Moreover, he suggests that poetry...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics