A Trouble Shared Is a Trouble Halved: Social Context and Status Affect Pain in Mouse Dyads

Laura Gioiosa; Chiarotti, Flavia; Alleva, Enrico; Laviola, Giovanni
January 2009
PLoS ONE;2009, Vol. 4 Issue 1, p1
Academic Journal
In mice behavioral response to pain is modulated by social status. Recently, social context also has been shown to affect pain sensitivity. In our study, we aimed to investigate the effects of interaction between status and social context in dyads of outbred CD-1 male mice in which the dominance/submission relationship was stable. Mice were assessed for pain response in a formalin (1% concentration) test either alone (individually tested-IT), or in pairs of dominant and subordinate mice. In the latter condition, they could be either both injected (BI) or only one injected (OI) with formalin. We observed a remarkable influence of social context on behavioral response to painful stimuli regardless of the social status of the mice. In the absence of differences between OI and IT conditions, BI mice exhibited half as much Paw-licking behavior than OI group. As expected, subordinates were hypoalgesic in response to the early phase of the formalin effects compared to dominants. Clear cut-differences in coping strategies of dominants and subordinates appeared. The former were more active, whereas the latter were more passive. Finally, analysis of behavior of the non-injected subjects (the observers) in the OI dyads revealed that dominant observers were more often involved in Self-grooming behavior upon observation of their subordinate partner in pain. This was not the case for subordinate mice observing the pain response of their dominant partner. In contrast, subordinate observers Stared at the dominant significantly more frequently compared to observer dominants in other dyads. The observation of a cagemate in pain significantly affected the observer's behavior. Additionally, the quality of observer's response was also modulated by the dominance/submission relationship.


Related Articles

  • Reconsidering Relational Autonomy. Personal Autonomy for Socially Embedded and Temporally Extended Selves. Baumann, Holger // Analyse & Kritik;dez2008, Vol. 30 Issue 2, p445 

    Most recent accounts of personal autonomy acknowledge that the social environment a person byes in, and the personal relationships she entertains, have some impact on her autonomy. Two kinds of conceptualizing social conditions are traditionally distinguished in this regard: Causally relational...

  • Cultivating Communication Skills. Macnamara, Looby // Permaculture Magazine;Fall2012, Issue 73, p56 

    The article discusses principles to help facilitate effective communication and listening. The importance of observation is emphasized. The barriers to communication are identified as well as ways to overcome them. Information is provided on the communication tool called think and listens or...

  • Who's got the Upper Hand? Hand Holding Behaviors Among Romantic Couples and Families. Pettijohn, Terry; Ahmed, Shujaat; Dunlap, Audrey; Dickey, Lauren // Current Psychology;Sep2013, Vol. 32 Issue 3, p217 

    The hand holding behavior of romantic couples and family dyads ( n = 886) in public locations around Myrtle Beach, South Carolina was observed. Over 90 % of males in heterosexual romantic couples, parents in parent child pairs, and older siblings in child sibling pairs tended to place their hand...

  • The relationship of individual and neighbourhood deprivation with morbidity in older adults: an observational study. Jordan, Kelvin P.; Hayward, Richard; Roberts, Eyitope; Edwards, John J.; Kadam, Umesh T. // European Journal of Public Health;Jun2014, Vol. 24 Issue 3, p396 

    The objective was to determine the relative association of social class and neighbourhood deprivation with primary care consultation for eight morbidities. In 18 047 survey responders aged ≥50 years, living in more deprived neighbourhoods was independently associated with new consultation...

  • Do People “Pop Out”? Mayer, Katja M.; Vuong, Quoc C.; Thornton, Ian M. // PLoS ONE;10/6/2015, Vol. 10 Issue 10, p1 

    The human body is a highly familiar and socially very important object. Does this mean that the human body has a special status with respect to visual attention? In the current paper we tested whether people in natural scenes attract attention and “pop out” or, alternatively, are at...

  • Social aspirations and choice of fertility: why can status motive reduce per-capita growth? Tournemaine, Frederic // Journal of Population Economics;Jan2008, Vol. 21 Issue 1, p49 

    To examine the relationship between social aspirations, fertility choices and growth performances, we develop a R&D-based model in which individuals care about the number of children they bring up and their social status. In such an economy, we find that stronger status motives have a negative...

  • Gender and Willingness to Confront Hurtful Messages from Romantic Partners. Miller, Courtney Waite; Roloff, Michael E. // Communication Quarterly;Aug2005, Vol. 53 Issue 3, p323 

    Based on a social role perspective, an individual's hurt and willingness to confront a face attack expressed by a romantic partner were hypothesized to vary with gender, type of face attack, and social context. Undergraduates responding to hypothetical scenarios revealed that when teased, women...

  • "Die Ränder brechen auf und sie brechen herein": Ein interkultureller Blick auf Ilma Rakusa und Karl-Markus Gauβ. Horvat, Vesna Kondrič // Modern Austrian Literature;2008, Vol. 41 Issue 3, p55 

    The article deals with two language-aware and form-conscious artists who express a strong drive toward aesthetic expression but never forget their immersion in social and historical environments. Karl-Markus Gauß and Ilma Rakusa, who gained their reputations as very subtle mediators between...

  • Know Your History, Queens! Pinardi, Mario // Outlook: Columbus;Oct2011, Vol. 16 Issue 5, p29 

    The article discusses the need for LGBT people to have knowledge about their community's history to serve as a catalyst in creating their own history. It notes that LGBT individuals who do not have knowledge about their community's history do not see the possible impact to others who have not...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics