Monkeying around with HIV vaccines: using rhesus macaques to define 'gatekeepers' for clinical trials

Shedlock, Devon J.; Silvestri, Guido; Weiner, David B.
October 2009
Nature Reviews Immunology;Oct2009, Vol. 9 Issue 10, p717
Academic Journal
Rhesus macaques are an important animal model for the study of human disease and the development of vaccines against HIV and AIDS. HIV vaccines have been benchmarked in rhesus macaque preclinical challenge studies using chimeric viruses made up of parts of HIV and simian immunodeficency viruses. However, the lack of efficacy in a recent clinical trial calls for a re-evaluation of the scientific assumptions regarding the predictive value of using data generated from rhesus macaques as a 'gatekeeper' for the advancement of candidate vaccines into the clinic. In this context, there is significant consensus among HIV vaccinologists that next-generation HIV vaccines must generate 'better' immunity in rhesus macaques than clinically unsuccessful vaccines generated using validated assays. Defining better immunity is the core challenge of HIV vaccine development in this system and is the focus of this Review.


Related Articles

  • AIDS vaccine models: Challenging challenge viruses. Feinberg, Mark B.; Moore, John P. // Nature Medicine;Mar2002, Vol. 8 Issue 3, p207 

    Discusses AIDS vaccine models particularly rhesus macaque models. Experimental infection of rhesus monkeys with various simian immunodeficiency virus strains of differing virulence; Use of simian/human immunodeficiency viruses (SHIVs) as challenge viruses; Difference between SHIV-89.6P and...

  • Understanding Challenge Viruses. McEnery, Regina // VAX;Sep2009, Vol. 7 Issue 9, p4 

    The article focuses on the effects of challenge viruses on animal models using rhesus macaques for AIDS vaccine research. Rhesus macaques are said to be optimal for animal models in AIDS vaccine research being that it is the only animal that could be infected with simian immunodeficiency virus...

  • The Rhesus Macaque Pediatric SIV Infection Model - A Valuable Tool in Understanding Infant HIV-1 Pathogenesis and for Designing Pediatric HIV-1 Prevention Strategies. Abel, Kristina // Current HIV Research;Jan2009, Vol. 7 Issue 1, p2 

    Worldwide, the AIDS pandemic continues almost relentlessly. Women are now representing the fastest growing group of newly infected HIV-1 infected patients. The risk of mother-to-child-transmission (MTCT) of HIV-1 increases proportionally as many of these women are of childbearing age. The...

  • A common rhesus macaque MHC class I molecule which binds a cytotoxic T-lymphocyte epitope in Nef of simian immunodeficiency virus. Horton, Helen; Rehrauer, William; Meek, Eliabeth C.; Shultz, Millicent A.; Piekarczyk, Marian S.; Jing, Peicheng; Carter, Donald K.; Steffen, Susan R.; Calore, Briana; Urvater, Julie A.; Vogel, Thorsten U.; Wilson, Nancy A.; Watkins, David I. // Immunogenetics;Jul2001, Vol. 53 Issue 5, p423 

    Focuses on the importance of simian immunodeficiency virus (SIV) infection of rhesus macaques as a model for the study of HIV infection in humans. Importance in controlling viral replication in infected hosts; Expansion on the utility of the rhesus macaque as a model for vaccine and pathogenesis...

  • Differential Tumor Necrosis Factor alpha Productionin Simian Immunodeficiency Virus--Infected... Newman, Gale W.; Adams, Donna L.; Maslow, Joel N.; Murphy-Corb, Michael; Didier, Peter J. // Clinical Infectious Diseases;3/1/1999, Vol. 28 Issue 3, p514 

    Characterizes the function of macrophages (Mphis) in Rhesus macaques infected with simian immunodeficiency virus and Mycobacterium avium to understand HIV and M. avium interactions. Mechanisms in diminishing tumor necrosis factor alpha production by M. avium; Occurrence of M. avium infections...

  • Novel Simian Foamy Virus infection of wild Indian rhesus macaque (Macaca mulatta). Nandi, Jayashree S.; Chhangani, Anil K.; Mohnot, Surendra M. // Retrovirology;Jan2011 Supplement 1, Vol. 8, pA215 

    An abstract of the research paper titled,"Innate and adaptive anti-viral immune responses in MS patients treated with interferon-beta", is presented.

  • What should we make of the HIV vaccine 'triumph'? Coghlan, Andy // New Scientist;10/3/2009, Vol. 204 Issue 2728, p10 

    The article weighs the significance of a clinical trial of an HIV vaccine in 2009. The trial, which was financed by the U.S. military and conducted by the Thai Ministry of Public Health, involved 16,000 volunteers in Thailand. Findings show that the vaccine, a combination of Alvac and Aidsvax...

  • Monkey business over AIDS vaccine. Weiss, Robin // BMJ: British Medical Journal (International Edition);10/12/91, Vol. 303 Issue 6807, p872 

    Focuses on the research in an attempt to develop an AIDS vaccine in Great Britain. Assessment on the protection of macaque monkeys against simian immunodeficiency virus (SIV), a close relative of HIV; Pathogenesis of HIV and SIV.

  • Of Monkeys and Medicine. Hyde, John // Advocate;1/30/90, Issue 543, p18 

    Examines the development of a vaccine for a simian form of AIDS in rhesus monkeys in the United States. Possibility of developing a human AIDS vaccine; Considerations regarding the human side of AIDS; Treatments for AIDS.


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics