TITLE

In vivo Study of Skin Mechanical Properties in Psoriasis Vulgaris

AUTHOR(S)
Dobrev, H.
PUB. DATE
September 2000
SOURCE
Acta Dermato-Venereologica;09/20/2000, Vol. 80 Issue 4
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
The aim of this study was to investigate the mechanical properties of the skin in psoriatic plaques before and after treatment with dithranol and in clinically uninvolved psoriatic skin in comparison with the skin of healthy controls. In total, 82 psoriatic plaques in 19 in-patients and 51 age-matched control subjects were studied with a non-invasive suction device (Cutometer). The plaques were characterized by statistically significant lower skin distensibility and elasticity, and a higher viscoelastic to elastic ratio compared with adjacent apparently normal skin. Delayed distension and hysteresis measured using a 2-mm diameter probe were decreased, but were increased when measured by a 8-mm diameter probe. These differences can be explained by the increased skin thickness in psoriasis and by the different aspects of skin mechanics determined by the 2 measuring probes. After treatment, the mechanical parameters of psoriatic plaques approached the values of adjacent control skin. The uninvolved volar forearm skin in psoriatic patients (2-mm diameter probe) showed statistically significant lower values of skin distensibility and higher values of viscoelasticity parameters compared with the skin of healthy control subjects. This suggests that the normal-appearing psoriatic skin is not entirely normal. The non-invasive method applied can be used for objective and quantitative evaluation of the effect of therapy in patients with psoriasis.
ACCESSION #
4342597

 

Related Articles

  • Flurandrenolide tape solves tough psoriatic lesions. Moyer, Paula // Dermatology Times;Dec98, Vol. 19 Issue 12, p10 

    Recommends the use of flurandrenolide tape in individuals with resistant psoriatic lesions. Comparison of response to flurandrenolide tape versus ointment and cream formulations; Percent of patients who exhibited improvements in sites treated with flurandrenolide; Low folliculitis rate; Side...

  • Systematic review of comparative efficacy and tolerability of calcipotriol in treating chronic plaque psoriasis. Ashcroft, Darren M.; Li Wan Po, Alain; Williams, Hywel C.; Griffiths, Christopher E.M. // BMJ: British Medical Journal (International Edition);04/08/2000, Vol. 320 Issue 7240, p963 

    Provides information on a study which evaluated the comparative efficacy and tolerability of topical calcipotriol in the treatment of mild to moderate chronic plaque psoriasis. Methods; Results and discussion; Conclusions.

  • Conservative Treatment Advised for Erythrodermic Psoriasis Patients. Kuznar, Wayne // Dermatology Times;May98, Vol. 19 Issue 5, p22 

    Focuses on the conservative therapy for erythrodermic psoriatic patients in the United States. Discussion on erythroderma; Differential diagnosis for psoriasis; Treatment.

  • Adalimumab.  // Reactions Weekly;5/8/2010, Issue 1300, p5 

    The article presents the case of a 50-year-old man who developed bullous pemphigoid (BP) while receiving adalimumab for psoriasis treatment.

  • Should general practitioners use dithranol? Donaldson, Judith; Cunliffe, W.J. // British Medical Journal (Clinical Research Edition);6/18/1983, Vol. 286 Issue 6382, p1939 

    Examines the treatment of dithranol for patients with psoriasis. Improvement on the cosmetic acceptability of some dithranol preparations; Effectiveness of dithranol application to the skin for one hour; Details on the conventional regimen of dithranol treatment.

  • Comparison of Betamethasone Valerate Solution with Phototherapy (UVB Comb) in Scalp Psoriasis Treatment. Braun, Rosemarie; Kåre Dotterud, Lars; Falk, Edvard // Acta Dermato-Venereologica;09/01/98, Vol. 78 Issue 5, p385 

    Compares the effectiveness of betamethasone valerate solution and phototherapy (UVB) comb in treating scalp psoriasis. Effect of betamethasone valerate solution and UVB comb on patients with scalp psoriasis; Grading of scalp psoriasis; Relapse of scalp psoriasis among the patients included in...

  • Psoriasis: Flaky is only an adjective for piecrusts. Schaefer, Ingrid K. // Dermatology Times;Nov97 Supplement, Vol. 18 Issue 11, pS3 

    Editorial. Contemplates on the advances in psoriasis care. Effectiveness of over-the-counter remedies on psoriasis; Challenge for manufacturers to come up with a more effective treatment for proriasis.

  • FDA okays psoriasis indication for a cyclosporine.  // Dermatology Times;Nov97 Supplement, Vol. 18 Issue 11, pS25 

    Presents highlights of the Neoral labeling related top psoriasis. Considerations before initiating treatment with the drug; Initial recommended dose for patients with psoriasis; Cautions against the use of Neoral for longer than a year.

  • Patient Education Critical Factor in Successful Tazarotene Use. Moore, Ian J.S. // Dermatology Times;Feb98, Vol. 19 Issue 2, p45 

    States that tazarotene can be used successfully as a first-line treatment in psoriatic patients when they are properly instructed about its use. Factors to consider in prescribing the drug for psoriasis treatment; Common side effects of psoriatic treatment; How to manage the side effects of...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics