TITLE

NeuroAIDS

AUTHOR(S)
Minagar, Alireza; Commins, Deborah; Alexander, J. Steven; Hoque, Romy; Chiappelli, Francesco; Singer, Elyse J.; Nikbin, Behrooz; Shapshak, Paul
PUB. DATE
January 2008
SOURCE
Molecular Diagnosis & Therapy;Jan2008, Vol. 12 Issue 1, p25
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
The neurological complications of AIDS (NeuroAIDS) include neurocognitive impairment and HIV-associated dementia (HAD; also known as AIDS dementia and HIV encephalopathy). HAD is the most significant and devastating central nervous system (CNS) complications associated with HIV infection. Despite recent advances in our knowledge of the clinical features, pathogenesis, and neurobiological aspects of HAD, it remains a formidable scientific and therapeutic challenge. An understanding of the mechanisms of HIV neuroinvasion, CNS proliferation, and HAD pathogenesis provide a basis for the interpretation of the diagnostic features of HAD and its milder form, HIV-associated minor cognitive/motor disorder (MCMD). Current diagnostic strategies are associated with significant limitations, but it is hoped that the use of biomarkers may assist researchers and clinicians in predicting the onset of the disease process and in evaluating the effects of new therapies.
ACCESSION #
38707605

 

Related Articles

  • Delirium as a disorder of consciousness. Bhat, Ravi; Rockwood, Kenneth // Journal of Neurology, Neurosurgery & Psychiatry;Nov2007, Vol. 78 Issue 11, p1167 

    Delirium is a common clinical phenomenon, often described as a disorder of consciousness. Delirium is commonly under recognised. The usual response to under recognition is to exhort practitioners to do a better job, but perhaps under recognition should instead be seen as a daily pragmatic...

  • A comparison of neuropsychiatric and cognitive profiles in delirium, dementia, comorbid delirium-dementia and cognitively intact controls. David J Meagher // Journal of Neurology, Neurosurgery & Psychiatry;Aug2010, Vol. 81 Issue 8, p876 

    PURPOSE: Delirium and dementia have overlapping features that complicate differential diagnosis. Delirium symptoms overshadow dementia symptoms when they co-occur, but delirium phenomenology in comorbid cases has not been compared to both conditions alone. METHODS: Consecutive adults with DSM-IV...

  • Escala revisada-98 para valoración del delirium (DRS-R-98): adaptación colombiana de la versión española. Franco, J. G.; Mejía, M. A.; Ochoa, S. B.; Ramírez, L. F.; Bulbena, A.; Trzepacz, P. T. // Actas Espanolas de Psiquiatria;may2007, Vol. 35 Issue 3, p170 

    Introduction. Delirium is associated with high morbidity and mortality. There are no available instruments validated for evaluation and follow-up of this syndrome in Columbia. Methods. An expert's panel adapted the Spanish DRS-R-98. In 110, randomly selected, medical-surgical hospitalized...

  • Evaluation of Dementia. Geldmacher, David S.; Whitehouse, Peter J. // New England Journal of Medicine;8/1/96, Vol. 335 Issue 5, p330 

    Presents an overview of dementia and discusses the importance of accurate diagnosis in order to determine the appropriate treatment and health care planning. Characteristics of dementia; Determining the most likely underlying disease; Suggested supplemental mental-status testing for patients...

  • Neurological signs of possible diagnostic value in the cognitive disorders clinic. Larner, A. J. // Practical Neurology (BMJ Publishing Group);Oct2014, Vol. 14 Issue 5, p332 

    The article discusses the author's views on the importance of neurological signs in establishing the etiology and diagnosis for neuropsychological deficiency in cognitive testing. He explains that neurological examinations usually consider the detailed history of the patient in order to...

  • THE STRANGE CASE OF DR JEKYLL AND MR HYDE: CAN WE EFFECTIVELY MANAGE SUDDEN BEHAVIOUR CHANGES IN THE DYING PATIENT? Cameron, David // CME: Continuing Medical Education;Jul2011, Vol. 29 Issue 7, p278 

    The article discusses delirium, an altered state of minds, characterised by confusion of recent onset and variable severity, the most common reason for a sudden change of behaviour in a seriously ill patient. It details that risk factors that predispose to delirium include advanced age and...

  • Delirium: Diagnosis and treatment in the older patient. Tueth, Michael J.; Cheong, Josepha A. // Geriatrics;Mar1993, Vol. 48 Issue 3, p75 

    Delirium is more common in older adults because of normal physiologic changes, increased incidence of medical illnesses, and increased medication use in this population. Older dementing patients are particularly predisposed to delirium because of associated neurologic abnormalities. Delirium...

  • Recognizing Delirium Superimposed on Dementia. Fick, Donna M.; Hodo, Denise M.; Lawrence, Frank; Inouye, Sharon K. // Journal of Gerontological Nursing;Feb2007, Vol. 33 Issue 2, p40 

    Delirium is a serious and prevalent problem that occurs in many hospitalized older adults. Delirium superimposed on dementia (DSD) occurs when a delirium occurs concurrently with a pre-existing dementia. DSD is typically under-recognized by medical and nursing staff. The current study measured...

  • Neuropsychiatric and Cognitive Symptoms in Spinocerebellar Ataxia: Relationship to Neuropathological Differences. McMurtray, Aaron M.; Saito, Erin; Perlman, Susan // Current Psychiatry Reviews;2008, Vol. 4 Issue 3, p157 

    The autosomal dominant spinocerebellar ataxias (SCA) are a heterogeneous group of disorders associated with progressive degeneration of the cerebellum and other brain regions to varying degrees. Neuropsychiatric and cognitive symptoms are now considered to be well established clinical features...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics