TITLE

Growth and Morphogenetic Factors in Bone Induction: Role of Osteogenin and Related Bone Morphogenetic Proteins in Craniofacial and Periodontal Bone Repair

AUTHOR(S)
Ripamonti, Ugo; Reddi, A. Hari
PUB. DATE
March 1992
SOURCE
Critical Reviews in Oral Biology & Medicine;1992, Vol. 3 Issue 1, p1
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Bone has considerable potential for repair as illustrated by the phenomenon of fracture healing. Repair and regeneration of bone recapitulate the sequential stages of development. It is well known that demineralized bone matrix has the potential to induce new bone formation locally at a heterotopic site of implantation. The sequential development of bone is reminiscent of endochondral bone differentiation during bone development. The collagenous matrix-induced bone formation is a prototype model for matrix-cell interactions in vivo. The developmental cascade includes migration of progenitor cells by chemotaxis, attachment of cells through fibronectin, proliferation of mesenchymal cells, and differentiation of bone. The bone inductive protein, osteogenin, was isolated by heparin affinity chromatography. Osteogenin initiates new bone formation and is promoted by other growth factors. Recently, the genes for osteogenin and related bone morphogenetic proteins were cloned and expressed. Recombinant osteogenin is osteogenic in vivo. The future prospects for bone induction are bright, and this is an exciting frontier with applications in oral and orthopaedic surgery.
ACCESSION #
36635126

 

Related Articles

  • 11th Annual Meeting of the Dutch Bone and Mineral Society.  // Calcified Tissue International;Nov2002, Vol. 71 Issue 5, p379 

    The article presents abstracts from the eleventh annual meeting of the "Dutch Bone and Mineral Society," held in the Netherlands, between November 8-9, 2001. Osteoblast differentiation has been described in three phases. Firstly a proliferation phase, followed by a phase in which extracellular...

  • Periosteum: A Highly Underrated Tool in Dentistry. Mahajan, Ajay // International Journal of Dentistry;2012, p1 

    The ultimate goal of any dental treatment is the regeneration of lost tissues and alveolar bone. Under the appropriate culture conditions, periosteal cells secrete extracellular matrix and form a membranous structure. The periosteum can be easily harvested from the patient's own oral cavity,...

  • Heterotopic Bone Formation About the Hip Undergoes Endochondral Ossification: A Rabbit Model. Tannous, Oliver; Stall, Alec; Griffith, Cullen; Donaldson, Christopher; Castellani, Rudolph; Pellegrini, Vincent // Clinical Orthopaedics & Related Research;May2013, Vol. 471 Issue 5, p1584 

    Background: Heterotopic ossification (HO) occurs most commonly after trauma and surgery about the hip and may compromise subsequent function. Currently available animal models describing the cellular progression of HO are based on exogenous osteogenic induction agents and may not reflect the...

  • endochondral bone formation.  // Taber's Cyclopedic Medical Dictionary (2009);2009, Issue 21, p766 

    An encyclopedia entry for "endochondral bone formation," which refers to one of two types of bone formation in skeletal development, is presented.

  • In Vitro Studies on the Regulation of Endochondral Ossification by Vitamin D. Boyan, Barbara D.; Schwartz, Zvi; Swain, Larry D. // Critical Reviews in Oral Biology & Medicine;1992, Vol. 3 Issue 1, p15 

    This article reports on endochondral ossification by vitamin D and its role in bone formation in the human body. The development of bones involves cell differentiation and maturation, as well as the mineralization of the extracellular matrix, chondrocytes, and osteoblasts. The article discusses...

  • Chronological histological changes during bone regeneration on a non-crosslinked atelocollagen matrix. Kagawa, Ryosuke; Kishino, Mitsunobu; Sato, Sunao; Ishida, Ken; Ogawa, Yuzo; Ikebe, Kazunori; Oya, Kaori; Ishimoto, Takuya; Nakano, Takayoshi; Maeda, Yoshinobu; Komori, Toshihisa; Toyosawa, Satoru // Journal of Bone & Mineral Metabolism;Nov2012, Vol. 30 Issue 6, p638 

    Cleavage of the antigenic telopeptide region from type I collagen yields atelocollagen, and this is widely used as a scaffold for bone regeneration combined with cells, growth factors, etc. However, neither the biological effect of atelocollagen alone or its contribution to bone regeneration has...

  • Repeated Distraction Osteogenesis for Excessive Vertical Alveolar Augmentation: A Case Report. Iida, Seiji; Nakano, Tamaki; Amano, Katsuhiko; Kogo, Mikihiko // International Journal of Oral & Maxillofacial Implants;May/Jun2006, Vol. 21 Issue 3, p471 

    In this article, a procedure involving 2-stage alveolar distraction osteogenesis using eccentric distraction devices for the augmentation of resorbed transplanted iliac bone following mandibular tumor resection is presented. A 6-month consolidation period was allowed between the first and second...

  • What's New in Dentistry. Kokich, Vincent // Angle Orthodontist;Jul2007, Vol. 77 Issue 4, p569 

    The article summarizes results of several studies related to dentistry published in several periodicals. A method was developed in which cysts-like materials and granulation tissue are eliminated from the tooth socket after extraction before implants are placed. A study in the "Journal of Dental...

  • The Role of Heparan Sulfate and Perlecan in Bone-regenerative Procedures. DeCarlo, A. A.; Whitelock, J. M. // Journal of Dental Research;Feb2006, Vol. 85 Issue 2, p122 

    Tissue engineering, grafting procedures, regeneration, and tissue remodeling are developing therapeutic modalities with great potential medical value, but these regenerative modalities are not as effective or predictable as clinicians and patients would like. Greater understanding of growth...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics