TITLE

Chronic renal failure in Sudanese children: aetiology and outcomes

AUTHOR(S)
Ali, El-Tigani; Abdelraheem, Mohamed; Mohamed, Reem; Hassan, Einas; Watson, Alan
PUB. DATE
February 2009
SOURCE
Pediatric Nephrology;Feb2009, Vol. 24 Issue 2, p349
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
The provision of tertiary paediatric nephrology facilities has led to increasing referrals of children with chronic renal failure (CRF). We report the aetiology and outcomes over 5 years, during which period the improving socio-economic situation has allowed increasing provision of dialysis and transplantation. The records of 205 children (124 male; 60.5%) who were referred to a tertiary paediatric nephrology unit in Khartoum between 2001 and 2006 with a glomerular filtration rate of less than 50 ml/min per 1.73 m2 body surface area were reviewed. The mean age at the time of diagnosis with CRF was 9.8 years (range 3 months–17 years). The aetiology was chronic glomerulonephritis in 52 (25.4%), congenital urological malformations in 36 (17.5%), urolithiasis in 19 (9.3%), hereditary nephropathy in 14 (6.8%), multisystem diseases in 4 (2%), and cause unknown in 80 (39.1%). Of the 205 children, 136 (63%) had reached end-stage renal failure, with chronic haemodialysis being undertaken in 48 (35.3%), intermittent peritoneal dialysis in 43 (31.6%), continuous ambulatory peritoneal dialysis in 17 (14.7%), and no treatment in 25 (18.4%). At the end of the study period 53 of the 205 (25.9%) remained on dialysis, 51 (25%) were on conservative treatment, 8 (3.9%) had received transplants, 48 (23.4%) had died, and 45 (22%) had been lost to follow-up. The results illustrate the geographical variations in CRF aetiology in different countries, which may be influenced by current patterns of referral as well as environmental and society factors. The large number with an unknown aetiology for their CRF requires further prospective investigation. We hope the current high mortality rate will improve with earlier referral, improved nutrition, family support, and better access to treatment modalities, especially the provision of kidney transplantation from living related donors.
ACCESSION #
36387421

 

Related Articles

  • Quality of life in children with chronic kidney disease (with child and parent assessments). Buyan, Necla; Türkmen, Mehmet; Bilge, Ilmay; Baskin, Esra; Haberal, Mehmet; Bilginer, Yelda; Mir, Sevgi; Emre, Sevinç; Akman, Sema; Ozkaya, Ozan; Fidan, Kibriya; Alpay, Harika; Kavukcu, Salih; Sever, Lale; Özçakar, Zeynep; Dogrucan, Nahide // Pediatric Nephrology;Aug2010, Vol. 25 Issue 8, p1487 

    Herein the results of a multicenter study from the Turkish Pediatric Kidney Transplantation Study Group are reported. The aims of this study were to compare the quality of life (QoL) scores of Turkish children who are dialysis patients (DP), renal transplant recipients (TR), and age-matched...

  • Maintenance dialysis in North American children and adolescents: A preliminary report. Alexander, Steven R.; Sullivan, E. Kenneth; Harmon, William E.; Stablein, Donald M.; Tejani, Amir // Kidney International Supplement;Oct1993, Issue 43, pS104 

    During 1992 the North American Pediatric Renal Transplant Cooperative Study (NAPRTCS) began to develop a pediatric Dialysis Patient Data Base by collecting data on pediatric patients who had received either hemodialysis (HD) or peritoneal dialysis (PD), or both, at a participating NAPRTCS...

  • Chronic renal insufficiency in children and adolescents: the 1996 annual report of NAPRTCS. Fivush, Barbara A.; Jabs, Kathy; Neu, Alicia M.; Kenneth Sullivan, E.; Feld, Leonard; Kohaut, Edward; Fine, Richard // Pediatric Nephrology;1998, Vol. 12 Issue 4, p328 

    The 1996 annual report of the Chronic Renal Insufficiency Arm of the North American Pediatric Renal Transplant Cooperative Study (NAPRTCS) summarizes descriptive data and highlights important features on 1,725 patients from 130 centers. This database contains information on patients with an...

  • Aortic stiffness in ESRD children before and after renal transplantation. Aoun, Bilal; Lorton, Fleur; Wannous, Hala; Lévy, Bernard; Ulinski, Tim // Pediatric Nephrology;Jul2010, Vol. 25 Issue 7, p1331 

    Cardiovascular complications are the main cause of death in end-stage renal failure in adult patients, but those complications start in childhood. Renal transplantation (RT) seems to reduce or even reverse certain abnormalities seen in dialyzed patients. Since RT seems to correct metabolic...

  • Renal function during and after childhood acute poststreptococcal glomerulonephritis. Herthelius, M.; Berg, Ulla // Pediatric Nephrology;1999, Vol. 13 Issue 9, p907 

    It is still debatable whether acute poststreptococcal glomerulonephritis (APSGN) can lead to permanent renal impairment. The clinical, immunological, and histological findings during the acute disease have been described thoroughly, however, the hemodynamic events are still poorly understood. In...

  • Poststreptococcal acute glomerulonephritis superimposed on bilateral renal hypoplasia. Naico-Yoshida, Y.; Hida, M.; Maruyama, Y.; Hori, N.; Awazu, M. // Clinical Nephrology;2005, Vol. 63 Issue 6, p477 

    An 8-year-old girl with preexisting chromic renal failure (CRF) due to bilateral renal hypoplasia presented with edema, gross hematuria and acute deterioration of renal function. The diagnosis of poststreptococcal acute glomerulonephritis (PSAGN) was made based on clinical presentation, red...

  • Factors related to psychosocial adjustment in children with end-stage renal failure. Fielding, Dorothy; Brownbridge, Garry // Pediatric Nephrology;1999, Vol. 13 Issue 9, p766 

    Psychological functioning and adjustment to dialysis were assessed in the families of 60 children and adolescents undergoing chronic dialysis. Sociodemographic factors, treatment variables, health status and satisfaction with health care provision were also measured. Correlation analyses...

  • Chronic dialysis in children and adolescents. The 2001 NAPRTCS Annual Report. Neu, Alicia M.; Ho, P. L. (Martin); McDonald, Ruth A.; Warady, Bradley A. // Pediatric Nephrology;Aug2002, Vol. 17 Issue 8, p656 

    The 2001 annual report of the North American Pediatric Renal Transplant Cooperative Study (NAPRTCS) registry includes data on 4,546 dialysis patients. Important trends in dialysis care include a significant increase in the use of peritoneal dialysis catheters with two cuffs (51.6% vs. 36.2%,...

  • The continuum of transition from paediatric to adult renal care. Watson, Alan R. // Journal of Renal Nursing;2010, Vol. 2 Issue 5, p214 

    The article focuses on managing the transition of children with renal disease from a paediatric renal unit (PRU) to an adult unit. It mentions that the management of chronic kidney disease (CKD) in children requires a multiprofessional team, and highlights the need for transition planning in...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics