Remission of metabolic syndrome following a 15-week low-calorie lifestyle change program for weight loss

Lundgren, J. D.; Malcolm, R.; Binks, M.; O'Neil, P. M.
January 2009
International Journal of Obesity;Jan2009, Vol. 33 Issue 1, p144
Academic Journal
Objective:To evaluate the rate of remission of metabolic syndrome (Met Syn) among patients undergoing a brief, low-calorie lifestyle change weight loss intervention and to compare the baseline characteristics of patients who were remitted and not remitted from Met Syn at post-treatment.Research Methods and Procedures:Obese adults (N=36) meeting criteria for Met Syn enrolled in an outpatient fee-for-service behavioral weight loss intervention. Participants were assessed on key Met Syn variables (waist circumference, blood pressure, triglycerides, high-density lipoprotein (HDL) cholesterol and fasting blood glucose) at pre- and post-treatment.Results:The majority of patients (61%) responded to treatment after a 9.9% mean weight loss. Although Met Syn responders did not differ significantly from Met Syn non-responders on any baseline Met Syn criterion variable, responders had significantly lower baseline body mass indices (BMI; kg/m2) and met criteria for fewer baseline Met Syn variables. As expected, Met Syn responders, compared with Met Syn non-responders, had significantly lower post-treatment waist circumference, systolic and diastolic blood pressures, triglycerides and fasting blood glucose. Patient groups did not differ significantly on weight lost (kg or %), or on the proportion of patients losing 10% of initial body weight.Discussion:In a community population, Met Syn responds to weight loss through a low-calorie lifestyle intervention; for some patients, however, the recommended 10% weight loss may not be enough for Met Syn remission.International Journal of Obesity (2009) 33, 144–150; doi:10.1038/ijo.2008.225; published online 18 November 2008


Related Articles

  • Increased Vaspin Levels Are Associated with Beneficial Metabolic Outcome Pre- and Post-Bariatric Surgery. Lu, HuiLing; Wamba, Ponce Cedric Fouejeu; Lapointe, Marc; Poirier, Paul; Martin, Julie; Bastien, Marjorie; Cianflone, Katherine // PLoS ONE;Oct2014, Vol. 9 Issue 10, p1 

    Purpose: Vaspin (visceral-adipose-tissue-derived-serine-protease-inhibitor) is a recently identified adipokine with putative insulin-sensitizing properties. Plasma vaspin responses to surgery-induced weight loss are sparse and contradictory. Design and Participants: We evaluated changes in...

  • Triglyceride Level Affecting Shared Susceptibility Genes in Metabolic Syndrome and Coronary Artery Disease. Kisfali, P.; Polgár, N.; Sáfrány, E.; Sümegi, K.; Melegh, B. I.; Bene, J.; Wéber, Á.; Hetyésy, K.; Melegh, B. // Current Medicinal Chemistry;Oct2010, Vol. 17 Issue 30, p3533 

    No abstract available.

  • Age- and Gender-Specific Components of the Metabolic Syndrome in 2228 First Graders: The PEP Family Heart Study. Schwandt, Peter; Bertsch, Thomas; Liepold, Evelyn; Haas, Gerda-Maria // Scientifica;2013, p1 

    Because first graders are critical for excess weight gain, we assessed components of the metabolic syndrome (MetS) using the pediatric definition of the International Diabetes Federation (IDF). We compared four MetS components as defined by the IDF with age- and gender-specific components in...

  • Community-based weight management in long-term heart transplant recipients: a pilot study. Salyer, Jeanne; Flattery, Maureen; Joyner, Pamela; Friend, Jennifer; Elswick Jr, R. K. // Progress in Transplantation;Dec2007, Vol. 17 Issue 4, p315 

    Background--Heart transplant recipients often suffer from obesity, dyslipidemia, and hypertension thought to be related to triple-drug immunosuppression and poor adherence to diet and exercise. A lifestyle intervention that allows recipients to attend a community-based weight management program...

  • Short-term Administration of Orlistat Reduced Daytime Triglyceridemia in Obese Women With the Metabolic Syndrome. Tzotzas, Themistoklis; Samara, Martha; Constantinidis, Theodoros; Tziomalos, Konstantinos; Krassas, Gerasimos // Angiology;Feb/Mar2007, Vol. 58 Issue 1, p26 

    The objective of this prospective, controlled, randomized study was to evaluate the effect of orlistat administration for 10 days on daytime capillary triglyceridemia in obese women with metabolic syndrome (MetSyn). Thirty-two obese, nondiabetic women with MetSyn were evaluated. The presence of...

  • Increased Brain Fatty Acid Uptake in Metabolic Syndrome. Karmi, Anna; Iozzo, Patricia; Viljanen, Antti; Hirvonen, Jussi; Fielding, Barbara A.; Virtanen, Kirsi; Oikonen, Vesa; Kemppainen, Jukka; Viljanen, Tapio; Guiducci, Letizia; Haaparanta-Solin, Merja; Någren, Kjell; Solin, Olof; Nuutila, Pirjo // Diabetes;Sep2010, Vol. 59 Issue 9, p2171 

    OBJECTIVE--To test whether brain fatty acid uptake is enhanced in obese subjects with metabolic syndrome (MS) and whether weight reduction modifies it. RESEARCH DESIGN AND METHODS--We measured brain fatty acid uptake in a group of 23 patients with MS and 7 age-matched healthy control subjects...

  • Bridging interventions before bariatric surgery in patients with BMI ≥ 50 kg/m2: a systematic review and meta-analysis. Lee, Yung; Dang, Jerry T.; Switzer, Noah; Malhan, Roshan; Birch, Daniel W.; Karmali, Shahzeer // Surgical Endoscopy;Nov2019, Vol. 33 Issue 11, p3578 

    Background: Bariatric surgery on patients with body mass index (BMI) ≥ 50 kg/m2, historically known as superobesity, is technically challenging and carries a higher risk of complications. Bridging interventions have been introduced for weight loss before...

  • WHAT YOU CAN DO. Bjerklie, David // Time International (South Pacific Edition);4/28/2003, Issue 16, p56 

    The article presents suggestions to reduce the risk of cardiovascular disease. Obesity leads to diabetes, which increases the risk of a heart attack. A low calorie diet with lots of vegetables and whole grains and regular exercise help in losing weight. Blood pressure and a low cholesterol level...

  • Weight loss with very-low-calorie diet and cardiovascular risk factors in moderately obese women: One-year follow-up study including ambulatory blood pressure monitoring. Pekkarinen, T; Takala, I; Mustajoki, P // International Journal of Obesity & Related Metabolic Disorders;Jul1998, Vol. 22 Issue 7, p661 

    OBJECTIVE: The beneficial effects of weight loss with a very-low-calorie diet (VLCD) on cardiovascular risk factors have been reported at the end of energy restriction. As the effects, especially on blood pressure, may not remain constant during weight maintenance, we studied the longer-term...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics