TITLE

3′UTR-Dependent Localization of a Purkinje Cell Messenger RNA in Dendrites

AUTHOR(S)
Rui Zhang; Xulun Zhang; Feng Bian; Xin-an Pu; Schilling, Karl; Oberdick, John
PUB. DATE
September 2008
SOURCE
Cerebellum;Sep2008, Vol. 7 Issue 3, p482
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Pcp2(L7) is a Purkinje cell-specific GoLoco domain protein that modulates activation of Gαi/o proteins by G protein-coupled receptors. A likely downstream effector of this pathway is the P-type Ca2+ channel, and thereby, the intrinsic electrophysiology of Purkinje cells could be modulated by Pcp2(L7). It has long been known that the Pcp2(L7) mRNA is abundantly localized in dendrites, suggesting the possibility of distal synthesis and local changes in levels of the protein. As a first step to uncover the trafficking and translational mechanisms for this mRNA, we have begun identifying the cis-acting sequences important for its localization in dendrites. Using expression of modified transgenes in vivo, we show that the 3′UTR, only 65 bases long, is necessary in this process.
ACCESSION #
34722811

 

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