TITLE

Computational Analyses of TBC Protein Family in Eukaryotes

AUTHOR(S)
Xinjiao Gao; Changjiang Jin; Yu Xue; Xuebiao Yao
PUB. DATE
June 2008
SOURCE
Protein & Peptide Letters;Jun2008, Vol. 15 Issue 5, p505
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Tre-2/Bub2/Cdc16 domain-containing proteins (TBC proteins) participate in wide range cellular processes. With computational approaches, 137 non-redundant TBC proteins from five model organisms were identified and classified into 13 subfamilies base on molecular evolutionary tree. This phylogenetic analysis provides useful functional annotation of newly-identified TBC proteins and guides for further experimentation.
ACCESSION #
33650909

 

Related Articles

  • Clamping down on exocytosis. Rowan, Alison // Nature Reviews Neuroscience;Aug2006, Vol. 7 Issue 8, p593 

    The article discusses research being done on the role of complexin, along with exocytotic SNARE proteins, in calcium-mediated vesicle fusion. It references a study by C. G. Giraudo in the June 22, 2006 issue of "Science." Synaptotagmin, when added on its own or in the presence of calcium, had...

  • Structural basis for the evolutionary inactivation of Ca2+ binding to synaptotagmin 4. Han Dai; Ok-Ho Shin; Machius, Mischa; Tomchick, Diana R.; Südhof, Thomas C .; Rizo, Josep // Nature Structural & Molecular Biology;Sep2004, Vol. 11 Issue 9, p844 

    The neuronal protein synaptotagmin 1 functions as a Ca2+ sensor in exocytosis via two Ca2+-binding C2 domains. The very similar synaptotagmin 4, which includes all the predicted Ca2+-binding residues in the C2B domain but not in the C2A domain, is also thought to function as a neuronal Ca2+...

  • The molecular machinery of synaptic vesicle exocytosis. Li, L.; Chin, L.-S. // Cellular & Molecular Life Sciences;May2003, Vol. 60 Issue 5, p942 

    : At the synapse, neurotransmitters are released via Ca2+-triggered exocytotic fusion of synaptic vesicles with the presynaptic plasma membrane. Synaptic vesicle exocytosis seems to share many basic principles and homologous proteins with other membrane fusion events. Conserved components of the...

  • Binding of the complexin N terminus to the SNARE complex potentiates synaptic-vesicle fusogenicity. Mingshan Xue; Craig, Timothy K.; Junjie Xu; Chao, Hsiao-Tuan; Rizo, Josep; Rosenmund, Christian // Nature Structural & Molecular Biology;May2010, Vol. 17 Issue 5, p568 

    Complexins facilitate and inhibit neurotransmitter release through distinct domains, and their function was proposed to be coupled to the Ca2+ sensor synaptotagmin-1 (Syt1). However, the mechanisms underlying complexin function remain unclear. We now uncover an interaction between the complexin...

  • SNAP Receptors.  // Encyclopedic Reference of Cancer;2001, p831 

    An encyclopedia entry for soluble N-ethyl maleimide-sensitive factor receptors is presented. They are required for synaptic vesicle exocytosis. Synaptic vesicles, according to the SNARE hypothesis, dock to the target membrane through the interactions of N-ethyl maleimide-sensitive fusion (NSF)...

  • Irreversible cell-cycle transitions are due to systems-level feedback. Novak, Bela; Tyson, John J.; Gyorffy, Bela; Csikasz-Nagy, Attila // Nature Cell Biology;Jul2007, Vol. 9 Issue 7, p724 

    The irreversibility of cell-cycle transitions is commonly thought to derive from the irreversible degradation of certain regulatory proteins. We argue that irreversible transitions in the cell cycle (or in any other molecular control system) cannot be attributed to a single molecule or reaction,...

  • A New Role for a Synaptotagmin Protein in Calcium-Dependent Exocytosis. JK, Jaiswal; S, Chakrabarti; NW, Andrews; SM, Simon // PLoS Biology;Aug2004, Vol. 2 Issue 8, p0 

    The hardest working molecules in cell biology, proteins abound in a dazzling variety of shapes and sizes to carry out an equally impressive array of tasks. Many proteins function within the cell, while others get shipped out to locations both near and far. Specialized organelles within the cell...

  • Synaptotagmins form a hierarchy of exocytotic Ca2+ sensors with distinct Ca2+ affinities. Sugita, Shuzo; Ok-Ho Shin; Weiping Han; Ye Lao; Südhof, Thomas C. // EMBO Journal;2/1/2002, Vol. 21 Issue 3, p270 

    Synaptotagmins constitute a large family of membrane proteins implicated in Ca2+-triggered exocytosis. Structurally similar synaptotagmins are differentially localized either to secretory vesicles or to plasma membranes, suggesting distinct functions. Using measurements of the Ca2+ affinities of...

  • Exocytosis in Rat Parotid Acini After in vitro Treatment with Forskolin is Accompanied by Cellular Redistribution of Regulatory Subunits of Cyclic AMP-dependent Protein Kinase. MEDNIEKS, M. I.; CHENG, L. F.; HAND, A. R. // Journal of Dental Research;Aug1986, Vol. 65 Issue 8, p1057 

    Incubation of rat parotid acinar tissue with 1 µmol/L forskolin resulted in progressive exocytosis which was virtually complete after a 30-minute incubation period. Cyclic AMP binding to protein kinase (cA-PK) regulatory (R) subunits, determined by photo-affinity labeling with [32P]-8-azido...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics