TITLE

A Simple Gas Chromatographic Method for the Simultaneous Determination and Pharmacokinetic Study of Tetramethylpyrazine Phosphate and Borneol in Mouse Plasma and Brain Tissue After Oral Administration of the Fufang Tetramethylpyrazine Phosphate Tablets

AUTHOR(S)
Xiao Yan-yu; Ping Qi-neng; Chen Zhi-peng
PUB. DATE
May 2008
SOURCE
Journal of Chromatographic Science;May2008, Vol. 46 Issue 5, p395
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
A rapid, sensitive, and simple gas chromatographic method with flame ionization detection is developed for the simultaneous determination of tetramethylpyrazine phosphate (TMPP) and borneol in mouse plasma and brain tissue. Sample preparations are carried out by deproteinization with an internal standard solution in methanol. The analytes and internal standard (dimethyl sulfoxide) are well-separated on an HP-5 MS capillary column. The analytical curves are linear over a wide concentration range of 0.02–40 µg/mL for both TMPP and borneol in plasma and brain tissue, with the intra- and inter-day precision (the relative standard deviation values) at less than 15%. TMPP and borneol are both stable under different conditions. The method described is successfully applied to the pharmacokinetic study of mouse plasma and brain tissue after oral administration of the Fufang TMPP and TMPP tablets to mice.
ACCESSION #
32952805

 

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