Addition of clopidogrel to aspirin may have increased risk for cardiovascular death in a primary prevention population

George, Susan; O'Malley, Patrick G.
March 2008
ACP Journal Club;Mar/Apr2008, Vol. 148 Issue 2, p8
Academic Journal
The article focuses on the randomized placebo-controlled trial investigating if the addition of clopidogrel to aspirin for primary prevention of cardiovascular disease (CVD) events increases risk for cardiovascular (CV) death in patients with risk factors but no history of CVD. The trial, conducted with 2289 patients (45 years of age), found out that in a primary prevention population, the addition of clopidogrel to aspirin did not reduce risk for CVD and may have increased risk for CV death.


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