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Heinrichs, Arianne
April 2007
Nature Reviews Genetics;Apr2007, Vol. 8 Issue 4, p252
Academic Journal
The article presents studies on the methylation status of histones, which are essential for gene regulation and chromatin structure. Methylation was modulated by histone methylases and demethylases. Christensen and others showed that retinoblastoma-binding protein-2 is a histone demethylases that binds the promoters of certain Hox genes in undifferentiated embryonic stem cells. Klose and others showed that RBP2-knockout mouse cells displayed increased transcription of certain cytokine genes.


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