TITLE

Size and stability of liposomes: A possible role of hydration and osmotic forces

AUTHOR(S)
Sabín, J.; Prieto, G.; Ruso, J. M.; Hidalgo-Álvarez, R.; Sarmiento, F.
PUB. DATE
August 2006
SOURCE
European Physical Journal E -- Soft Matter;Aug2006, Vol. 20 Issue 4, p401
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Dynamic light scattering and electrophoretic mobility measurements have been used to characterize the size, size distribution and zeta potentials (ζ-potentials) of egg yolk phosphatidylcholine (EYPC) liposomes in the presence of monovalent ions ( Na+ and K+). To study the stability of liposomes the Derjaguin-Landau-Verwey-Overbeek (DLVO) theory has been extended by introducing the hydrated radius of the adsorbed ions onto the liposome surfaces. The decrease of liposome size is explained on the basis of the membrane impermeability to some ions which generate osmotic forces, which leads to evacuate water from liposome inside.
ACCESSION #
22297949

 

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