TITLE

A concise synthesis of α-D-ribofuranosyl alkylphosphonates — Putative substrate intermediates for the carbon–phosphorous lyase system

AUTHOR(S)
Yan Luo; Zechel, David L.
PUB. DATE
April 2006
SOURCE
Canadian Journal of Chemistry;Apr2006, Vol. 84 Issue 4, p743
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Carbon–phosphorous lyase is a multienzyme system found in many species of bacteria that is distinguished by its ability to hydrolyze a broad array of unactivated alkylphosphonates. α-D-Ribofuranosyl alkylphosphonates are potential metabolic intermediates generated by the carbon–phosphorous lyase pathway. Here we describe a facile synthesis of α-D-ribofuranosyl alkylphosphonates using β-D-ribofuranosyl trichloracetimidate as a glycosyl donor.
ACCESSION #
21197104

 

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