Human stem cells go native in mouse brains

Coghlan, Andy
December 2005
New Scientist;12/17/2005, Vol. 188 Issue 2530, p8
The article reports on the impact of injecting embryonic stem cells (ESCs) into two-week-old mouse fetuses. When human ESCs were injected into the brains of two-week-old mouse fetuses, they developed and functioned like normal mouse cells. They were not rejected by the mouse's immune system, and even grew to the same size as mouse cells. The finding that human ESCs can fit in so well in their new home is encouraging news for researchers hoping to use them to treat neurological diseases. It also lessens ethical concerns about inadvertently creating animals with part-human brains when therapies are tested.


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