TITLE

Calciphylaxis in pediatric end-stage renal disease

AUTHOR(S)
Imam, Abubakr A.; Mattoo, Tej K.; Kapur, Gaurav; Bloom, David A.; Valentini, Rudolph P.
PUB. DATE
December 2005
SOURCE
Pediatric Nephrology;Dec2005, Vol. 20 Issue 12, p1776
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Calciphylaxis is a rare, but life-threatening complication of end-stage renal disease (ESRD) that has been reported mostly in adult patients. The exact etiology is unknown, but the disease is commonly associated with a high calcium-phosphorus product and elevated levels of parathyroid hormone (PTH). We herein review the published reports on calciphylaxis in ESRD patients less than 18 years old and report the case of a patient with severe calciphylaxis who presented with lower extremity pain, muscle tenderness and difficulty in walking. The serum PTH was low, and the calcium-phosphorus product was normal. The diagnosis of calciphylaxis was confirmed by a muscle biopsy. Treatment with low calcium peritoneal dialysate and substitution of calcium-based phosphorus binders with sevelamer (Renagel) was unsuccessful. The patient’s clinical condition progressed to extensive soft tissue calcification and ulcerating skin lesions. Nine months after the onset of symptoms, the patient died of cardiopulmonary arrest.
ACCESSION #
18855961

 

Related Articles

  • Predictors of growth response to rhGH in short children before and after renal transplantation. Wuhl, Elke; Haffner, Dieter; Tonshoff, Burkhard; Mehls, Otto // Kidney International Supplement;Oct1993, Issue 43, pS76 

    Many children with chronic renal failure (CRF) present with a reduced height and a reduced height velocity resulting in diminished final height irrespective of renal replacement therapy. Recombinant human growth hormone (rhGH) has become a new treatment modality for short renal patients, and the...

  • Recurrent disease in renal allografts. Cameron, J. Stewart // Kidney International Supplement;Oct1993, Issue 43, pS91 

    Recurrent or de novo diseases account for only 5% of graft failure in children, but have much to teach us about mechanisms. In children, almost the only metabolic disease with recurrence is type I hyperoxaluria, in which the poor long-term results of isolated renal transplantation makes combined...

  • Validity of cystatin C/creatinine ratio in pediatric kidney disease. Park, Se; Shin, Jae // Clinical & Experimental Nephrology;Oct2012, Vol. 16 Issue 5, p814 

    No abstract available.

  • Growth and development of nondialyzed children with chronic renal failure. Kleinknecht, Claire; Broyer, Michel; Huot, Danièle; Marti-Henneberg, Carles; Dartois, Anne-Marie // Kidney International Supplement;Nov1983, Issue 15, pS-40 

    Thirty-four children with severe kidney disease, either congenital (32 cases) or developing at birth, were followed until age 5 to 19 years. Overall growth retardation corresponded to −2.5 SD below the mean normal values. The retardation occurred almost exclusively before therapy for it...

  • Worldwide demographic aspects of chronic renal failure in children. Gusmano, Rosanna; Perfumo, Francesco // Kidney International Supplement;Jun1993, Issue 41, pS-31 

    Incidence of chronic renal failure in children is not yet clearly known. In recent years it has been evaluated on the basis of the number of patients accepted into dialysis-transplantation programs and is thus underestimated, as registries do not list children who are not treated for technical...

  • Antenatal oligohydramnios of renal origin: long-term outcome. Ilka Klaassen; Thomas J. Neuhaus; Dirk E. Mueller-Wiefel; Markus J. Kemper // Nephrology Dialysis Transplantation;Feb2007, Vol. 22 Issue 2, p432 

    Background. Prognosis of fetuses with renal oligohydramnios (ROH) is often still regarded as poor. Neonatal complications and the long-term follow-up of fetuses with ROH in two pediatric centres are described.Method. 23 fetuses (16 males, 7 females) were included as patients. Primary diseases...

  • CHRONIC RENAL FAILURE IN CHILDREN; ETIOLOGY AND CLINICAL PRESENTATION. Sajid, Nisar Khan; Ahmad, Shakil; Sarwar, Imran // Professional Medical Journal;2014, Vol. 21 Issue 2, p280 

    Introduction: Chronic renal failure is defined as progressive and irreversible loss of renal functions that gradually progress to end-stage renal disease. The etiology of chronic renal failure in childhood correlates closely with the age of patient at the time when the renal failure is first...

  • Stimulating growth in uremic children. Fine, Richard N. // Kidney International;Jul1992, Vol. 42 Issue 1, p188 

    Reports on a case of a four-year-old boy who has been diagnosed with renal insufficiency secondary to bilateral renal dysplasia. Manifestations of the condition; Formula recommended as dietary supplement for the boy; Factors causing growth retardation in children with chronic renal failure;...

  • Progressive encephalopathy in children with chronic renal insufficiency in infancy. Rotundo, Alberto; Nevins, Thomas E.; Lipton, Meryl; Lockman, Lawrence A.; Mauer, S. Michael; Michael, Alfred F. // Kidney International;Mar1982, Vol. 21 Issue 3, p486 

    A retrospective analysis of children with renal failure during the first year of life revealed that 20 of 23 patients developed profound neurologic abnormalities. The encephalopathy was characterized by developmental delay, microcephaly, hypotonia, seizures, dyskinesia, and EEG abnormalities. No...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics