Gross, Michael; Holte, Sarah; Seage, George R.; Buchbinder, Susan P.; Metzger, David S.; Mayer, Kenneth H.
February 2000
AIDS Education & Prevention;Feb2000, Vol. 12 Issue 1, p71
Academic Journal
This article reports that administration of antiretroviral medications-recommended to prevent HIV infection after occupational exposure-has not been evaluated for safety or efficacy following non occupational exposure. Although plausible, the safety and biological efficacy of oral chemoprophylaxis in the setting of possible HIV exposure through sexual contact or injection drug use is not known. Because biological efficacy is likely to depend on the receipt of medication very soon after potential exposure, and possibly on scrupulous adherence to the regimen for the entire recommended dosing period, the practical effectiveness of this strategy in nonoccupational settings also is unknown. Evaluating the safety, efficacy, and effectiveness of postexposure chemoprophylaxis in nonoccupational settings will require well-designed and carefully conducted studies. Despite these caveats and uncertainties, there remain important public health policy issues related to use of oral chemoprophylaxis for non-occupational exposures that can be addressed only through well-designed studies.


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