Paralyzing the two-faced BOTOX

Brazil, Melanie
November 2003
Nature Reviews Drug Discovery;Nov2003, Vol. 2 Issue 11, p859
Academic Journal
Reports on a study by researchers at the US Army Medical Research Institute of Infectious Diseases, the National Cancer Institute, and the University of Nebraska Medical Center which identified several nonpeptidic small-molecule inhibitors of BoNT (botulinum neurotoxins) serotype A. Need to develop therapeutic countermeasures against BoNTs which can be highly toxic in aerosol form and could be used in a terrorist attack; Danger of BoNT which binds to surface receptors on nerve terminals and eventually leads to paralysis; Discovery of a common pharmacophore for the identified BoNT/A LC (light chain) inhibitors.


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