Olfactory screening test in mild cognitive impairment

Eibenstein, A.; Fioretti, A. B.; Simaskou, M. N.; Sucapane, P.; Mearelli, S.; Mina, C.; Amabile, G.; Fusetti, M.
July 2005
Neurological Sciences;Jul2005, Vol. 26 Issue 3, p156
Academic Journal
Mild cognitive impairment (MCI) is a transient status between physiologic ageing and dementia. Each year more than 12% of subjects with MCI develop Alzheimer’s disease. This study evaluated the presence of an olfactory deficit in amnesic MCI (aMCI) patients. Twenty–nine patients diagnosed with aMCI and a homogeneous control group of 29 subjects were enrolled in the study. Olfactory function was assessed by the Sniffin’ Sticks Screening Test (SSST) and the Mini Mental State Examination, the Clinical Dementia Rating, the Geriatric Depression Scale and the Mental Deterioration Battery were used to evaluate the neurocognitive status. aMCI patients showed a significant impairment of their olfactory identification compared to controls (SSST score: 8.3±2.1 vs. 10.8±0.9; p<0.001). These results suggest that olfactory tests should be part of the diagnostic armamentarium of pre–clinical dementia. A long–term follow up might confirm the olfactory identification function as an early and reliable marker in the diagnosis of pre–clinical dementia.


Related Articles

  • What are the Causes of Late-Life Cognitive Decline? Isaacson, Richard S. // Neurology Alert;Oct2013, Vol. 32 Issue 2, p9 

    WITH THE FIRST WAVE OF THE BABY BOOMER GENERATION NEARING THEIR 70s, and considering that age is the number one risk factor for cognitive decline, determining the causal relationships behind progression of dementia is essential. Managing pre-symptomatic cognitive decline from a standpoint of...

  • White matter damage in frontotemporal dementia and Alzheimer's disease measured by diffusion MRI. Yu Zhang; Schuff, Norbert; Du, An-Tao; Rosen, Howard J.; Kramer, Joel H.; Gorno-Tempini, Maria Luisa; Miller, Bruce L.; Weine, Michael W. // Brain: A Journal of Neurology;Sep2009, Vol. 132 Issue 9, p2579 

    Frontotemporal dementia (FTD) and Alzheimer's disease are sometimes difficult to differentiate clinically because of overlapping symptoms. Using diffusion tensor imaging (DTI) measurements of fractional anisotropy (FA) can be useful in distinguishing the different patterns of white matter...

  • Cerebral metabolic correlates of four dementia scales in Alzheimer’s disease. Salmon, E.; Lespagnard, S.; Marique, P.; Peeters, F.; Herholz, K.; Perani, D.; Holthoff, V.; Kalbe, E.; Anchisi, D.; Adam, S.; Collette, F.; Garraux, G. // Journal of Neurology;Mar2005, Vol. 252 Issue 3, p283 

    Different scales can be used to evaluate dementia severity in Alzheimer’s disease (AD). They do assess different cognitive or functional abilities, but their global scores are frequently in mutual correlation. Functional imaging provides an objective method for the staging of dementia...

  • Validation of the Addenbrooke’s Cognitive Examination for Detecting Early Alzheimer’s Disease and Mild Vascular Dementia in a German Population. Alexopoulos, P.; Greim, B.; Nadler, K.; Martens, U.; Krecklow, B.; Domes, G.; Herpertz, S.; Kurz, A. // Dementia & Geriatric Cognitive Disorders;2006, Vol. 22 Issue 5/6, p385 

    We assessed the diagnostic accuracy of the German version of the Addenbrooke’s Cognitive Examination (ACE) in identifying early Alzheimer’s disease (AD) and mild vascular dementia (VaD) in comparison with the conventional Mini-Mental State Examination (MMSE). The study refers to 50...

  • Early detection of dementia and depression. Eisdorfer, Carl; Rovner, Barry W.; Whitehouse, Peter J. // Patient Care;11/15/2001, Vol. 35 Issue 21, p30 

    Provides information on dementia and depression in old age. Age-related memory loss in Alzheimer's disease; Characteristics of patients at risk to dementia and depression; Social implications of cognitive impairment; Factors that trigger depression.

  • Confronting Alzheimer's Disease. Okie, Susan // New England Journal of Medicine;9/22/2011, Vol. 365 Issue 12, p1069 

    The article looks at the efforts to confront Alzheimer's disease in the U.S. Doctors are discouraged by the federal government and private groups from actively searching for early dementia with the use of brief screening tests for cognitive impairment. New diagnostic criteria were published by...

  • Alzheimer's. Cowley, Geoffrey; Underwood, Anne // Newsweek;1/31/2000, Vol. 135 Issue 5, p46 

    Discusses Alzheimer's disease, which is expected to rise in incidence as life expectancy increases. Discoveries about how the placques from Alzheimer's destroy the brain; Role of beta amyloid (A-beta) protein and tau molecules; Genetic pathology of Alzheimer's; Environmental triggers and...

  • Semantic Markers in the Diagnosis of Neurodegenerative Dementias. Cuetos, Fernando; Rodríguez-Ferreiro, Javier; Menéndez, Manuel // Dementia & Geriatric Cognitive Disorders;2009, Vol. 28 Issue 3, p267 

    Background: The search for early cognitive markers of Alzheimer’s disease (AD) has focused on episodic memory and spatiotemporal orientation. However, recent research suggests that semantic memory is also impaired in the preclinical stages of AD. Methods: Age- and education-matched groups...

  • Literature Review of the Clock Drawing Test as a Tool for Cognitive Screening. Pinto, Elisabete; Peters, Ruth // Dementia & Geriatric Cognitive Disorders;2009, Vol. 27 Issue 3, p201 

    Background/Aims: The Clock Drawing Test (CDT) is used in clinical practice for the screening of cognitive disorders. This systematic review aims to present and discuss the CDT scoring methods available in the literature, in order to find differences in administration and utility of the CDT....


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics