Pilot study of a home-based aerobic exercise program for sedentary cancer survivors treated with hematopoietic stem cell transplantation

Wilson, R. W.; Jacobsen, P. B.; Fields, K. K.
April 2005
Bone Marrow Transplantation;Apr2005, Vol. 35 Issue 7, p721
Academic Journal
Summary:We report a pilot study of a home-based aerobic exercise program in a group of 17 adult hematopoietic stem cell transplant (HSCT) recipients. Participants had received no cancer treatment for at least 6 months and reported leisure time physical activity less than 20?min per day and fewer than three times a week during the previous month. Following baseline assessments of aerobic fitness, fatigue symptoms, and quality of life, participants were placed on home-based aerobic exercise programs consisting of 20-40?min of activity in the target heart rate zone (40-60%predicted heart rate reserve) delivered in three to five sessions per week for 12 weeks. Subjects were supplied with electronic heart rate monitors and we encouraged program adherence using weekly telephone contacts and exercise diaries. In all, 32 of the 42 qualified candidates consented (acceptance=76%). Of these, 17 kept appointments for baseline assessments, four did not complete the study (attrition=46%), and no exercise-related adverse events were reported. Scores on measures of aerobic fitness, fatigue severity, and physical well-being improved (signed ranks test; P<0.05) during program participation. Our findings suggest that individually prescribed, home-based aerobic exercise is an acceptable, safe, and potentially effective intervention for improving physical functioning and fatigue in sedentary HSCT recipients.Bone Marrow Transplantation (2005) 35, 721-727. doi:10.1038/sj.bmt.1704815 Published online 7 February 2005


Related Articles

  • The hunt for cancer-initiating cells: a history stemming from leukemia. Buzzeo, M. P.; Scott, E. W.; Cogle, C. R. // Leukemia (08876924);Aug2007, Vol. 21 Issue 8, p1619 

    Conventional cancer therapies are plagued by disease relapses due to incomplete eradication of cancer-initiating cells. Evidence for cancer-initiating cells originally arose from studies in hematology and leukemia. Lessons learned from hematopoietic stem cells laid the bedrock for understanding...

  • A revised scheme for developmental pathways of hematopoietic cells: the myeloid-based model. Kawamoto, Hiroshi; Wada, Haruka; Katsura, Yoshimoto // International Immunology;Feb2010, Vol. 22 Issue 2, p65 

    Blood cells comprise very diverse cell types with a wide range of crucial functions; however, they share a common progenitor cell type—the hematopoietic stem cell (HSC). Clarifying how HSCs differentiate into these diverse cell types is important for understanding how they attain their...

  • Controlling stem cell fate one substrate at a time. Garrison, Brian S.; Rossi, Derrick J. // Nature Immunology;Mar2010, Vol. 11 Issue 3, p193 

    The article focuses on the research by researcher L. Reavie and his colleagues regarding the role of the ubiquitinproteasome system in determining hematopoietic stem cell (HSC) fate. They propose a stem cell regulation in which modulation of protein stability by the ubiquitin system is used to...

  • Use of Human Embryonic Stem Cells to Understand Hematopoiesis and Hematopoietic Stem Cell Niche. Islam, Mohammad Saiful; Ni, Zhenya; Kaufman, Dan S. // Current Stem Cell Research & Therapy;Sep2010, Vol. 5 Issue 3, p245 

    Intensive research of hematopoiesis using human embryonic stem cells (hESC) as a unique starting cell population has enabled differentiation and isolation of diverse hematopoietic cell lineages. However, there has been only limited success in derivation of hematopoietic stem cells (HSCs) capable...

  • Evaluation of ex vivo expansion and engraftment in NOD-SCID mice of umbilical cord blood CD34+cells using the DIDECO‘Pluricell System’. Astori, G.; Adami, V.; Mambrini, G.; Bigi, L.; Cilli, M.; Facchini, A.; Falasca, E.; Malangone, W.; Panzani, I.; Degrassi, A. // Bone Marrow Transplantation;Jun2005, Vol. 35 Issue 11, p1101 

    Summary:The Dideco‘Pluricell System’is a commercially available closed device composed of an expansion chamber and a kit of certified reagents that allow haematopoietic stem cell expansion. We have expanded seven umbilical cord blood (UCB) samples following the manufacturer's...

  • Homing and Long-Term Engraftment of Long- and Short- Term Renewal Hematopoietic Stem Cells. Liansheng Liu; Papa, Elaine F.; Dooner, Mark S.; Machan, Jason T.; Johnson, Kevin W.; Goldberg, Laura R.; Quesenberry, Peter J.; Colvin, Gerald A. // PLoS ONE;Feb2012, Vol. 7 Issue 2, p1 

    Long-term hematopoietic stem cells (LT-HSC) and short-term hematopoietic stem cells (ST-HSC) have been characterized as having markedly different in vivo repopulation, but similar in vitro growth in liquid culture. These differences could be due to differences in marrow homing. We evaluated this...

  • Negative cell-cycle regulators cooperatively control self-renewal and differentiation of haematopoietic stem cells. Walkley, Carl R.; Fero, Matthew L.; Chien, Wei-Ming; Purton, Louise E.; McArthur, Grant A. // Nature Cell Biology;Feb2005, Vol. 7 Issue 2, p172 

    Haematopoietic stem cells (HSCs) are capable of shifting from a state of relative quiescence under homeostatic conditions to rapid proliferation under conditions of stress. The mechanisms that regulate the relative quiescence of stem cells and its association with self-renewal are unclear, as is...

  • Functional Analysis of Human Hematopoietic Stem Cell Gene Expression Using Zebrafish. Eckfeldt, Craig E.; Mendenhall, Eric M.; Flynn, Catherine M.; Tzu-Fei Wang; Pickart, Michael A.; Grindle, Suzanne M.; Ekker, Stephen C.; Verfaillie, Catherine M. // PLoS Biology;Aug2005, Vol. 3 Issue 8, p1449 

    Although several reports have characterized the hematopoietic stem cell (HSC) transcriptome, the roles of HSC-specific genes in hematopoiesis remain elusive. To identify candidate regulators of HSC fate decisions, we compared the transcriptome of human umbilical cord blood and bone marrow...

  • Immune activation modulates hematopoiesis through interactions between CD27 and CD70. Nolte, Martijn A.; Arens, Ramon; van Os, Ronald; van Oosterwijk, Michiel; Hooibrink, Berend; van Lier, René A. W.; van Oers, Marinus H. J. // Nature Immunology;Apr2005, Vol. 6 Issue 4, p412 

    The differentiation of hematopoietic stem cells into mature blood cell lineages is tightly regulated. Here we report that CD27, which is expressed on stem and early progenitor cells in bone marrow, can be important in this process. Deletion of CD27 increased the myeloid colony-forming potential...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics