Molecular determinants of exocytosis

Bruns, Dieter; Jahn, Reinhard
January 2002
Pflugers Archiv European Journal of Physiology;Jan2002, Vol. 443 Issue 3, p333
Academic Journal
Membrane fusion processes occur throughout the cell. Among those, exocytosis of secretory organelles is probably one of the fastest fusion events animal cells can achieve. Structural and functional studies have provided a conceptual framework and a starting point for our mechanistic understanding of how SNARE proteins may contribute to the final step in exocytosis.


Related Articles

  • SNARE complex zipping as a driving force in the dilation of proteinaceous fusion pores. Jackson, Meyer B. // Journal of Membrane Biology;May2010, Vol. 235 Issue 2, p89 

    The assembly of SNARE proteins into a tight complex has been hypothesized to drive membrane fusion. A model of the initial fusion pore as a proteinaceous channel formed by SNARE proteins places their membrane anchors in separate membranes. This leaves the possibility of a final assembly step...

  • Molecular control of compound exocytosis. Thorn, Peter; Gaisano, Herbert // Communicative & Integrative Biology;Jan/Feb2012, Vol. 5 Issue 1, p61 

    Exocytosis is the process of fusion of a membrane-bound vesicle with the cell membrane and subsequent release of the vesicle content to the outside. It is now widely accepted that SNAREs (soluble N-ethylmaleimide-sensitive factor attachment protein receptors) proteins are key components in the...

  • Real-time visualization of complexin during single exocytic events. An, Seong J.; Grabner, Chad P.; Zenisek, David // Nature Neuroscience;May2010, Vol. 13 Issue 5, p577 

    Understanding the fundamental role of soluble NSF attachment protein receptor (SNARE) complexes in membrane fusion requires knowledge of the spatiotemporal dynamics of their assembly. We visualized complexin (cplx), a cytosolic protein that binds assembled SNARE complexes, during single exocytic...

  • The molecular machinery of synaptic vesicle exocytosis. Li, L.; Chin, L.-S. // Cellular & Molecular Life Sciences;May2003, Vol. 60 Issue 5, p942 

    : At the synapse, neurotransmitters are released via Ca2+-triggered exocytotic fusion of synaptic vesicles with the presynaptic plasma membrane. Synaptic vesicle exocytosis seems to share many basic principles and homologous proteins with other membrane fusion events. Conserved components of the...

  • Searching for the silver lining. White, Judith M.; Castle, J. David // Nature Structural & Molecular Biology;May2005, Vol. 12 Issue 5, p382 

    Highlights a research study which reveals the structure of a SNARE transmembrane domain and supports a model of exocytosis via hemifusion. Ways by which hemifusion serves as a common intermediate in many, if not all, biological fusion reactions; Importance of membrane fusion for a diverse array...

  • Shp1 and Ubx2 are adaptors of Cdc48 involved in ubiquitin-dependent protein degradation. Schuberth, Christian; Richly, Holger; Rumpf, Sebastian; Buchberger, Alexander // EMBO Reports;Aug2004, Vol. 5 Issue 8, p818 

    Known activities of the ubiquitin-selective AAA ATPase Cdc48 (p97) require one of the mutually exclusive cofactors Ufd1/Npl4 and Shp1 (p47). Whereas Ufd1/Npl4 recruits Cdc48 to ubiquitylated proteins destined for degradation by the 26S proteasome, the UBX domain protein p47 has so far been...

  • MEMBRANE DYNAMICS: Family ties. Gagescu, Raluca // Nature Reviews Molecular Cell Biology;Dec2001, Vol. 2 Issue 12, p874 

    Discusses research on the relation between tethering factors and the protein families that drive membrane fusion. Reference to a study by Sean Munro and colleagues published in "Developmental Cell" magazine; Proteins identified in Saccharomyces cerevisiae; Relation of the deletion mutants with...

  • EnSNAREd by the Sperm Acrosome. Kurnar, Supriya // PLoS Biology;Oct2005, Vol. 3 Issue 10, p1 

    This article reports that researchers Gerardo De Blas, Carlos Roggero, Claudia Tomes, and Luis Mayorga have elucidated the molecular mechanics of membrane fusion by studying the single vesicle of the sperm, the acrosome. Enzymes released from the acrosome facilitate contact between the sperm and...

  • A common lipid links Mfn-mediated mitochondrial fusion and SNARE-regulated exocytosis. Seok-Yong Choi; Ping Huang; Jenkins, Gary M.; Chan, David C.; Schiller, Juergen; Frohman, Michael A. // Nature Cell Biology;Nov2006, Vol. 8 Issue 11, p1255 

    Fusion of vesicles into target membranes during many types of regulated exocytosis requires both SNARE-complex proteins and fusogenic lipids, such as phosphatidic acid. Mitochondrial fusion is less well understood but distinct, as it is mediated instead by the protein Mitofusin (Mfn). Here, we...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics