TITLE

Peripheral Blood Lymphocyte Subsets in Acute Human Melioidosis

AUTHOR(S)
Ramsay, S. C.; Ketheesan, N.; Norton, R.; Watson, A.-M.; LaBrooy, J.
PUB. DATE
July 2002
SOURCE
European Journal of Clinical Microbiology & Infectious Diseases;Jul2002, Vol. 21 Issue 7, p566
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
This article discusses the pathology of acute human melioidosis. Melioidosis is a gram-negative bacterial infection caused by Burkholderia pseudomallei. Although it often occurs in individuals with coexistent disease predisposing to immunosuppression, it also occurs in apparently normal individuals. However, its pathogenesis remains poorly understood. In human melioidosis clinical studies have demonstrated elevation of TNF-alpha [3], IFN-gamma, IL-2 [4], IL-6, and IL-10 [3] as well as other cytokines and chemokines.
ACCESSION #
15685761

 

Related Articles

  • Two Randomized Controlled Trials of Ceftazidime Alone versus Ceftazidime in Combination with Trimethoprim-Sulfamethoxazole for the Treatment of Severe Melioidosis. Chierakul, Wirongrong; Anunnatsiri, Siriluck; Short, Jennifer M.; Maharjan, Bina; Mootsikapun, Piroon; Simpson, Andrew J. H.; Limmathurotsakul, Direk; Cheng, Allen C.; Stepniewska, Kasia; Newton, Paul N.; Chaowagul, Wipada; White, Nicholas J.; Peacock, Sharon J.; Day, Nicholas P.; Chetchotisakd, Ploenchan // Clinical Infectious Diseases;10/15/2005, Vol. 41 Issue 8, p1105 

    Background. Two antibiotic regimens are used commonly in Thailand for the initial treatment of severe melioidosis: ceftazidime in combination with trimethoprim-sulfamethoxazole (TMP-SMX) and ceftazidime mono-therapy. It is not known whether TMP-SMX provides an additional benefit. Methods. Two...

  • Immunospecific Responses to Bacterial Elongation Factor Tu during Burkholderia Infection and Immunization. Nieves, Wildaliz; Heang, Julie; Asakrah, Saja; Bentrup, Kerstin Hönerzu; Roy, Chad J.; Morici, Lisa A. // PLoS ONE;2010, Vol. 5 Issue 12, p1 

    Burkholderia pseudomallei is the etiological agent of melioidosis, a disease endemic in parts of Southeast Asia and Northern Australia. Currently there is no licensed vaccine against infection with this biological threat agent. In this study, we employed an immunoproteomic approach and...

  • Cutaneous Meliodidosis and Necrotizing Fasciitis Caused by Burkholderia pseudomallei. Yi-Shi Wang; Chin-Ho Wong; Kurup, Asok // Emerging Infectious Diseases;Nov2003, Vol. 9 Issue 11, p1484 

    In areas where melioidosis is endemic, stress on the healthcare system is substantial. Because clinical manifestations are protean, the illness is difficult to diagnose, and cutaneous Burkholderia pseudomallei infections can progress to necrotizing fasciitis. While it is an uncommon complication...

  • Intensity of Rainfall and Severity of Melioidosis, Australia. Currie, Bart J.; Jacups, Susan P. // Emerging Infectious Diseases;Dec2003, Vol. 9 Issue 12, p1538 

    In a 12-year prospective study of 318 culture-confirmed cases of melioidosis from the Top End of the Northern Territory of Australia, rainfall data for individual patient locations were correlated with patient risk factors, clinical parameters, and outcomes. Median rainfall in the 14 days...

  • Meliodosis. Sheehy, Thomas W.; Deller, John J.; Weber, David R. // Annals of Internal Medicine;Oct67, Vol. 67 Issue 4, p897 

    Editorial. Presents information on melioidosis, a disease of men and animals, which was reported among U.S. citizens in or recently returned from Southeast Asia since May 1966. Information on acute and chronic melioidosis; Use of chloramphenicol for treatment.

  • Burkholderia pseudomallei Traced to Water Treatment Plant in Australia. Inglis, Timothy J.J.; Henderson, Mandy; Clair, Adele; Sampson, Judy; O'Reilly, Lyn; Garrow, Stuart C.; Cameront, Bob // Emerging Infectious Diseases;Jan/Feb2000, Vol. 6 Issue 1, p56 

    Burkholderia pseudomallei was isolated from environmental specimens 1 year after an outbreak of acute melioidosis in a remote coastal community in northwestern Australia. B. pseudomallei was isolated from a water storage tank and from spray formed in a pH-raising aerator unit. Pulsed-field gel...

  • Melioidosis in New Caledonia. Le Hello, Simon; Currie, Bart J.; Godoy, Daniel; Spratt, Brian G.; Mikulski, Marc; Lacassin, Flore; Garin, Benoit // Emerging Infectious Diseases;Oct2005, Vol. 11 Issue 10, p1607 

    Recognized melioidosis-endemic areas are widening. In the South Pacific, melioidosis is endemic in New Caledonia, northern Australia, and Papua New Guinea. We report the first 4 documented cases of human melioidosis from New Caledonia. Molecular typing of 2 Burkholderia pseudomallei isolates...

  • Multiplex qPCR for reliable detection and differentiation of Burkholderia mallei and Burkholderia pseudomallei. Janse, Ingmar; Hamidjaja, Raditijo A.; Hendriks, Amber C. A.; van Rotterdam, Bart J. // BMC Infectious Diseases;2013, Vol. 13 Issue 1, p1 

    Background: Burkholderia mallei and B. pseudomallei are two closely related species of highly virulent bacteria that can be difficult to detect. Pathogenic Burkholderia are endemic in many regions worldwide and cases of infection, sometimes brought by travelers from unsuspected regions, also...

  • Chlorination and pH of drinking water do not correlate with rates of melioidosis in the Northern Territory, Australia Cheng, Allen C.; Mayo, Mark J.; Gal, Daniel; Currie, Bart J. // Transactions of the Royal Society of Tropical Medicine & Hygiene;Sep2003, Vol. 97 Issue 5, p511 

    Abstract: Prompted by 2 outbreaks of melioidosis with fatalities linked to culture-positive drinking water, wetheorized that there may be a correlation between low drinking water pH or lack of chlorination and the rate of melioidosis in rural communities in tropical Australia. However, following...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics