Peripheral Blood Lymphocyte Subsets in Acute Human Melioidosis

Ramsay, S. C.; Ketheesan, N.; Norton, R.; Watson, A.-M.; LaBrooy, J.
July 2002
European Journal of Clinical Microbiology & Infectious Diseases;Jul2002, Vol. 21 Issue 7, p566
Academic Journal
This article discusses the pathology of acute human melioidosis. Melioidosis is a gram-negative bacterial infection caused by Burkholderia pseudomallei. Although it often occurs in individuals with coexistent disease predisposing to immunosuppression, it also occurs in apparently normal individuals. However, its pathogenesis remains poorly understood. In human melioidosis clinical studies have demonstrated elevation of TNF-alpha [3], IFN-gamma, IL-2 [4], IL-6, and IL-10 [3] as well as other cytokines and chemokines.


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