TITLE

Expression of Integrin Fraction and Adhesion Molecules on Human Granulosa Cells and Its Relation with Oocyte Maturity and Follicular Steroidogenesis

AUTHOR(S)
Clavero, A.; Castilla, J. A.; Martinez, L.; Mendoza, N.; Fontes, J.; Maid#Onado, V.
PUB. DATE
June 2004
SOURCE
Journal of Assisted Reproduction & Genetics;Jun2004, Vol. 21 Issue 6, p187
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Purpose: To study the correlation between the expression of integrin fractions and adhesion molecules on granulosa cells (GC) and follicular development. Methods: GC and follicular fluid (FF) were obtained at oocyte retrieval for ICSI. Expression of adhesion molecules on GC was studied by flow cytometry. Statistics were evaluated using the Student it test and simple linear regression analysis. Results: α5 integrin fraction was significantly (p < 0.01) higher, while α6 fraction and CD9 were significantly (p < 0.01 and p <0.001, respectively) lower in GC from FF with metaphase II oocytes. A direct significant correlation was observed between FF progesterone and the α5 expression on GC (r = 0.54). In contrast, an inverse significant correlation was observed between FF progesterone level and the expression of α6 and CD9 (r = -0.40 and -0.41, respectively). Conclusions: The expression pattern for integrin fractions and adhesion molecules may be of predictive value in assessing the state of differentiation of the human follicle.
ACCESSION #
15032414

 

Related Articles

  • Infertility therapy-associated multiple pregnancies (births): an ongoing epidemic. Adashi, Eli Y.; Barri, Pedro N.; Berkowitz, Richard; Braude, Peter; Bryan, Elizabeth; Carr, Judith; Cohen, Jean; Collins, John; Devroey, Paul; Frydman, René; Gardner, David; Germond, Marc; Gerris, Jan; Gianaroli, Luca; Hamberger, Lars; Howles, Colin; Jones Jr, Howard; Lunenfeld, Bruno; Pope, Andrew; Reynolds, Meredith // Reproductive BioMedicine Online (Reproductive Healthcare Limited;Nov2003, Vol. 7 Issue 5, p515 

    Details a meeting of international thought leaders in the field of reproductive medicine, sponsored by the Bertarelli Foundation, which was held at the Weill Medical College, Cornell University from April 12 to 13, 2003. Factor associated with the problem of multiple gestation; Implications of...

  • Little consensus on egg freezing. Maher, Brendan // Nature;10/25/2007, Vol. 449 Issue 7165, p958 

    The article focuses on the scientific issues surrounding the practice of egg freezing for women facing fertility treatment in the U.S. According to a findings presented during the annual meeting of the American Society for Reproductive Medicine (ASRM) in Washington D.C., egg freezing does not...

  • ESHRE PGD Consortium ‘Best practice guidelines for clinical preimplantation genetic diagnosis (PGD) and preimplantation genetic screening (PGS)’. A.R. Thornhill; C.E. deDie-Smulders; J.P. Geraedts; J.C. Harper; G.L. Harton; S.A. Lavery; C. Moutou; M.D. Robinson; A.G. Schmutzler; P.N. Scriven; K.D. Sermon; L. Wilton // Human Reproduction;Jan2005, Vol. 20 Issue 1, p35 

    Among the many educational materials produced by the European Society of Human Reproduction and Embryology (ESHRE) are guidelines. ESHRE guidelines may be developed for many reasons but their intent is always to promote best quality practices in reproductive medicine. In an era in which...

  • Endometrial Pinopode and αvβ3 Integrin Expression.  // Fertility Weekly;4/19/2004, p2 

    The article focuses on a research study, which states that endometrial pinopode and αv&b.beta;3 integrin expression, conducted by researcher Jaume Ordi and colleagues, published in the Journal of Assisted Reproduction and Genetics. Researchers in Spain report that no reduction of...

  • The Effects of Maternal Exposure to Perfluorinated Chemicals on Fecundity.  // Fertility Weekly;5/25/2009, p6 

    The article reports on the effects of perfluorinated chemicals exposure on human fecundity. It notes that fecundity may be reduced through common maternal exposure to prefluorooctanoate (PFOA) and perfluorooctane (PFOS) which both belong to a class of perfluorinated chemicals. A study which aims...

  • Conference Abstracts. Mitchell, Julie // Fertility Weekly;12/9/2002, p20 

    Presents information on various conference abstracts concerning human fertility and reproductive health. Topic on endometrial expression and chromosomal location of the porcine bone morphogenic protein receptor-IB gene; Subject of using conditional gene inactivation to study signaling pathways...

  • Contrasting selected reproductive challenges of today with those of antiquity--the past is prologue. Jones, Christopher A.; Scott Sills, Eric // Ulster Medical Journal;Sep2013, Vol. 82 Issue 3, p150 

    Viewing human history through a medical lens provides a renewed appreciation for today's vexing reproductive challenges, as some modern dilemmas are actually continuations of similar challenges experienced long ago. Certainly there are many examples of assisted fertility therapy that were...

  • For the career woman with foresight: frozen eggs. McGovern, Celeste // Report / Newsmagazine (BC Edition);7/22/2002, Vol. 29 Issue 15, p59 

    Reports that women can freeze their eggs in an effort to prolong their fertility. Use of services from the CHA Fertility Center, which freezes eggs for a fee; Likelihood that a frozen egg will survive; Costs of the freezing procedure.

  • Acquiring, Distributing, and Disposing of Potential Human Life: The Current Status of Human Embryos Beyond Chicanery II. Reich, J. Brad // Journal of Management Policy & Practice;2013, Vol. 14 Issue 3, p11 

    A human embryo is, by medical definition, "...the developing organism from fertilization to the end of the eighth week." In the largely un-settled legal realm, a human embryo is "...[neither] 'persons' or 'property', but occupy[ing] an interim category that entitles them to special respect...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics