Expression of Integrin Fraction and Adhesion Molecules on Human Granulosa Cells and Its Relation with Oocyte Maturity and Follicular Steroidogenesis

Clavero, A.; Castilla, J. A.; Martinez, L.; Mendoza, N.; Fontes, J.; Maid#Onado, V.
June 2004
Journal of Assisted Reproduction & Genetics;Jun2004, Vol. 21 Issue 6, p187
Academic Journal
Purpose: To study the correlation between the expression of integrin fractions and adhesion molecules on granulosa cells (GC) and follicular development. Methods: GC and follicular fluid (FF) were obtained at oocyte retrieval for ICSI. Expression of adhesion molecules on GC was studied by flow cytometry. Statistics were evaluated using the Student it test and simple linear regression analysis. Results: α5 integrin fraction was significantly (p < 0.01) higher, while α6 fraction and CD9 were significantly (p < 0.01 and p <0.001, respectively) lower in GC from FF with metaphase II oocytes. A direct significant correlation was observed between FF progesterone and the α5 expression on GC (r = 0.54). In contrast, an inverse significant correlation was observed between FF progesterone level and the expression of α6 and CD9 (r = -0.40 and -0.41, respectively). Conclusions: The expression pattern for integrin fractions and adhesion molecules may be of predictive value in assessing the state of differentiation of the human follicle.


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