TITLE

Genetic programs regulating HSC specification, maintenance and expansion

AUTHOR(S)
Lessard, Julie; Faubert, Am´┐Żlie; Sauvageau, Guy
PUB. DATE
September 2004
SOURCE
Oncogene;9/20/2004 Review, Vol. 23 Issue 43, p7199
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
All mature blood cells originate from a small population of self-renewing pluripotent hematopoietic stem cells (HSCs). The capacity to self-renew characterizes all stem cells, whether normal or neoplastic. Interestingly, recent studies suggest that self-renewal is essential for tumor cell maintenance, implicating that this process has therapeutic relevance. Unfortunately, the molecular bases for self-renewal of vertebrate cells remain poorly defined. This article will focus on the developmental mechanisms underlying fetal and adult HSC homeostasis. Specifically, distinctions between genetic programs regulating HSC specification (identity), self-renewal (in both fetal and adult) and differentiation/commitment will be discussed with a special emphasis on transcriptional and chromatin regulators.Oncogene (2004) 23, 7199-7209. doi:10.1038/sj.onc.1207940
ACCESSION #
14437806

 

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