TITLE

Radiolabelled PSMA PET/CT in breast cancer. A systematic review

AUTHOR(S)
Bertagna, Francesco; Albano, Domenico; Cerudelli, Elisabetta; Gazzilli, Maria; Tomasini, Davide; Bonù, Marco; Giubbini, Raffaele; Treglia, Giorgio
PUB. DATE
January 2020
SOURCE
Nuclear Medicine Review;2020, Vol. 23 Issue 1, p32
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
BACKGROUND: Radiolabelled prostate-specific membrane antigen (PSMA)-based PET/CT is a whole-body imaging technique currently performed for the detection of prostate cancer lesions. PSMA has been also demonstrated to be expressed by the neovasculature of many other solid tumours. The aim of this review is to evaluate the possible diagnostic role of radiolabelled PSMA PET/CT in breast cancer. MATERIAL AND METHODS: A comprehensive literature search of the PubMed/MEDLINE, Scopus, Embase and Cochrane Library databases was conducted to find relevant published articles about the diagnostic performance of radiolabelled PSMA PET/CT in breast cancer. RESULTS: The comprehensive computer literature search revealed 652 articles. On reviewing the titles and abstracts, 640 articles were excluded because the reported data were not within the field of interest of this review. Twelve articles were selected and retrieved in full-text version; no additional study was found when screening the references of these articles. In total, 12 articles were included in the systematic review. CONCLUSIONS: Further studies enrolling a wider population are needed to clarify the real clinical and diagnostic role of radiolabelled PSMA in this setting and its possible position in the diagnostic flow-chart.
ACCESSION #
141641959

 

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