TITLE

Effectiveness of Exercise Programs on Patients with Dementia: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

AUTHOR(S)
Xudong Li; Rui Guo; Zhenhong Wei; Jing Jia; Chaojun Wei
PUB. DATE
November 2019
SOURCE
BioMed Research International;11/22/2019, p1
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Exercise programs have been introduced to improve cognitive function, whereas studies showed inconsistent results regarding the effectiveness of exercise programs on patients with dementia. -is study aimed to summarize randomized controlled trials (RCTs) to assess the effect of exercise programs on cognition, activities of daily living (ADL), and depression in elderly with dementia. We systematically screened PubMed, Embase, and the Cochrane library for relevant studies throughout November 21, 2018. -e pooled standardized mean differences (SMDs) with 95% confidence intervals (CIs) were employed to calculate cognition, ADL, and depression by using random-effects model. A total of 20 RCTs with 2,051 dementia patients were included in final quantitative meta-analysis. -ere were no significant differences between exercise programs and control regarding cognition (SMD: 0.44; 95% CI: - 0.21-1.09; P = 0.183), ADL (SMD: 0.50; 95% CI: - 0.03-1.02; P = 0.066), and depression (SMD: - 0.43; 95% CI: - 0.90-0.05; P = 0.077). Sensitivity analysis results indicated that exercise programs might play an important role in cognition and ADL, whereas the depression level was unaltered by the exclusion of any particular study. Subgroup analyses indicated that exercise programs were associated with increased cognitive levels if the mean age of patients was <80.0 years when compared with usual care and studies with low quality. Moreover, the ADL level was significantly increased in patients receiving exercise programs versus usual care. -ese results suggested that exercise programs might play an important role in cognition and ADL in patients with dementia. -ese results required further verification by large-scale RCTs, especially for depression outcomes.
ACCESSION #
141408343

 

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