┼×tefania, Todea; Gabriel, Hancu
January 2019
Acta Medica Marisiensis;2019 Supplement, Vol. 65, p69
Academic Journal
Background: Obesity is a medical condition in which the subject carries an excess weight; and represents a great problem in modern society. Obesity is related to multiple reasons, including diet, lifestyle, pathological conditions, genetic factors or the use of certain medications. It can increase risks in developing health problems but losing weight can be sometimes a difficult and frustrating problem. Several treatment options are available, including regular exercise and dietary changes but also pharmacological treatment. Objective: The aim of the study is an evaluation of the actual state of anorexigenic medication, taking in consideration the controversies related to antiobesity drugs involving failures in clinical development and withdrawals due to adverse effects. Material and methods: Comparing several studies regarding pharmacokinetic, pharmacologic and pharmacotoxicologic profiles of certain drugs can be a solution and an important tool in understanding obesity pathology and the processes underlying its pharmacological treatment. Results: Although based on historical data we can state that anti-obesity medication failed to meet expectations, however in recent years an emergence of new therapeutic options can be observed. The aim of modern pharmacotherapy is to loose weight, but also to improve other associated pathologies such as diabetes, hyperlipidemia and cardiovascular diseases. Conclusions: Obesity represents a growing worldwide pandemic with high health and economic consequences. Pharmacotherapy combined with lifestyle changes are the current choices used to diminish the consequences of this pathological condition and its sequalae. However pharmacological treatment has a significant history of health risks, consequently new treatment pathways are a necessity and a challenge for modern medicine.


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