TITLE

THE PREDICTIVELY FAVORABLE FACTORS OF CLINICAL PREGNANCY AT FROZEN EMBRYO TRANSFER PROTOCOLS IN PATIENTS WITH REPEATED IMPLANTATION FAILURES

AUTHOR(S)
SULIMA A. N.; VORONAYA V. V.; DAVYDOVA A. A.; RYBALKA A. N.; DIZHA M. A.
PUB. DATE
June 2019
SOURCE
New Armenian Medical Journal;Jun2019, Vol. 13 Issue 2, p87
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
This article is devoted to a problem of forecasting of the frozen embryo transfer results at patients with repeated implantation failures (more than two) and to identification of the favorable factors of clinical pregnancy. The research included retrospective and prospective stages. At a retrospective stage for the identification of repeated implantation failures risk factors, 200 outpatient cards of the patients undergoing of artificial reproductive technologies were analyzed. 100 patients had repeated implantation failures at frozen embryo transfer in the anamnesis, 100 patients had only one successful frozen embryo transfer, and pregnancy occurred. The influence of various schemes of replacement hormonal therapy on endometrium and the results of frozen embryo transfer was studied at prospective stage. Patients of a retrospective stage with repeated implantation failures which depending on the estrogen medication (an estradiol valerate or 17β-estradiol) as a part of replacement hormonal therapy were divided into two equivalent groups and entered a prospective stage. Predictively favorable factors of clinical pregnancy in frozen embryo transfer cycles at patients with the repeated implantation failures are two and more gynecologic diseases in the anamnesis; two and more extragenital diseases; two and more pelvic organs surgeries in the anamnesis; two and more intrauterine interventions in the anamnesis; two and more factors of infertility and also absence of pathologic morphological changes at endometrium after miscarriages in the anamnesis and duration of infertility is less than 10 years. Also, the expressed expression of endometrium α-estrogen receptors and a marker of proliferative activity of endometrium (Ki-67), according to an immunohistochemical research in an early proliferative phase of a previous menstrual cycle to frozen embryo transfer (from 9 to 11 day) using the replaceable hormonal therapy is evidenced by the clinical pregnancy. Identification of repeated implantation failures risk factors at the patients undergoing of frozen embryo transfer is an unfortunate factor of clinical pregnancy. The expressed expression of endometrium α-estrogen receptors and a marker of proliferative activity of endometrium (Ki-67) are associated with increasing of clinical pregnancy rate in frozen embryo transfer protocols at the analyzed patients' group. Estradiol blood level does not correlate with the level of α-estrogen receptors expression and Ki-67 marker in endometrium.
ACCESSION #
136850663

 

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