TITLE

Potent antitumour activity of (-)epigallocatechin gallate: indications from in vitro, in vivo and in silico studies

AUTHOR(S)
Narayanan, Samarendra; Ramchandran, Balaji; Rajendiran, Satheesh; Chandra, Sarbani; Tiwari, Atul; Rajarethinam, Ravisankar; Kureeckal Vasudev, Ramesh
PUB. DATE
January 2016
SOURCE
Current Science (00113891);1/25/2016, Vol. 110 Issue 2, p187
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Antitumour efficacy of (-)epigallocatechin-3-gallate (EGCG) was evaluated in vitro against the cancer cell lines BxPC-3 (pancreatic cancer), A549 (lung cancer), SH-SY5Y (neuroblastoma), MDA-MB-231 and MCF-7 (breast cancer); in vivo in nude mice by tumour growth inhibition of pancreatic cancers (BxPC-3, MIAPaCa-2), breast cancer (MDA-MB-231) and in silico by docking studies. EGCG significantly inhibited these cancer cell lines in vitro and showed significant tumour reduction in vivo. EGCG docked on to the Her-2 receptor (1N8Y) and the tubulin dimer receptor at a site other than the existing docetaxel ligand. Overall our results suggest that EGCG has potent antineoplastic activity.
ACCESSION #
112465791

 

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