TITLE

Fusogenic Viral Envelopes as Potent Vehicles for Gene Transfer

AUTHOR(S)
Ponimaskin, Evgeni G.; Schmidt, Michael F.G.
PUB. DATE
September 2001
SOURCE
Current Genomics;Sep2001, Vol. 2 Issue 3, p261
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
The development of methods for efficiently introducing foreign genes into living cells provides novel tools to investigate intracellular processes at the molecular level. In addition, the development of suitable delivery vehicles for in vivo gene transfer is a prerequisite for clinical application of therapeutic genes. This review will summarize the current status of the development of both viral as well as non-viral vectors for gene therapy. In addition, we also discuss novel gene-delivery vehicles based on viral envelopes containing fusogenic spike proteins originated from different myxoviruses. These recombinant viral envelopes or virosomes could be viewed as hybrid vectors combining both viral and non-viral strategies, and are well suited for a wider application in therapeutic gene and drug delivery.
ACCESSION #
11134600

 

Related Articles

  • A Transporter Gene (Sodium Iodide Symporter) for Dual Purposes in Gene Therapy: Imaging and Therapy. Je-Yoel Cho, N. // Current Gene Therapy;Dec2002, Vol. 2 Issue 4, p393 

    Radioiodide uptake (RAIU) in thyroid follicular epithelial cells, mediated by a plasma membrane transporter, sodium iodide symporter (NIS), provides a first step mechanism for thyroid cancer detection by radioiodide injection and effective radioiodide treatment for patients with invasive,...

  • Rapid crossing of the pulmonary endothelial barrier by polyethylenimine/DNA complexes. Goula, D; Becker, N; Lemkine, G F; Normandie, P; Rodrigues, J; Mantero, S; Levi, G; Demeneix, B A // Gene Therapy;Mar2000, Vol. 7 Issue 6, p499 

    Intravenous administration could become a delivery route of choice for prophylactic and curative gene therapies on condition that genes cross the capillary barrier and reach target tissues without being degraded. We investigated the kinetics and process of transgene delivery through mouse lung...

  • HSV-1 VP22 augments adenoviral gene transfer to CNS neurons in the retina and striatum in vivo. Kretz, A.; Wybranietz, W.A.; Hermening, S.; Lauer, U.M.; Isenmann, S. // Molecular Therapy;May2003, Vol. 7 Issue 5, p659 

    One of the obstacles to efficient vector-mediated gene transfer to the CNS is limited transduction of target neurons. The VP22 tegument protein of HSV-1 can cross biological membranes and translocate the VP22 protein from primarily transfected cells to many surrounding cells in vitro. Here, we...

  • Gene transfer medicinal products.  // WHO Drug Information;2002, Vol. 16 Issue 4, p275 

    Cites efforts of the World Health Organization's Clinical Gene Transfer Monitoring Group to develop a general definition of gene transfer medicinal products. Brief history of gene therapy.

  • 158. Gene Therapy for Chronic Pain Control: Perspectives of HSV-1 Mediated Gene Transfer to Supraspinal Centres Martins, Isabel; Pinto, Marta; Wilson, Steven; Lima, Deolinda; Tavares, Isaura // Molecular Therapy;Jun2005, Vol. 11, p63 

    An abstract of the article "Gene Therapy for Chronic Pain Control: Perspectives of HSV-1 Mediated Gene Transfer to Supraspinal Centres," by Isabel Martins, Marta Pinto, Steven Wilson, Deolinda Lima and Isaura Tavares is presented.

  • 433. Gene Therapy of Epilepsy by Adenovirus-Mediated Tetanus Toxin Light Chain Gene Transfer Yang, Jun; Teng, Qingshan; Garrity-Moses, Mary E.; Federici, Thais; Najm, Imad; Chabardes, Stephan; Moffitt, Michael; Boulis, Nicholas M. // Molecular Therapy;Jun2005, Vol. 11, p168 

    An abstract of the article "Gene Therapy of Epilepsy by Adenovirus-Mediated Tetanus Toxin Light Chain Gene Transfer," by Jun Yang, Qingshan Teng, Mary E. Garrity-Moses, Thais Federici, Imad Najm, Stephan Chabardes, Michael Moffitt and Nicholas M. Boulis is presented.

  • 445. Combinatorial Antiangiogenic Gene Therapy by Nonviral Gene Transfer Using the Sleeping Beauty Transposon Causes Tumor Regression and Improves Survival in Mice Bearing Intracranial Human Glioblastoma Ohlfest, John R.; Demorest, Zachary L.; Motooka, Yasuhiko; Vengco, Isabelita; Oh, Seunguk; Chen, Eleanor; Scappaticci, Frank A.; Ekker, Stephen C.; Low, Walter C.; Freese, Andrew B.; Largaespada, David A. // Molecular Therapy;Jun2005, Vol. 11, p172 

    An abstract of the article "Combinatorial Antiangiogenic Gene Therapy by Nonviral Gene Transfer Using the Sleeping Beauty Transposon Causes Tumor Regression and Improves Survival in Mice Bearing Intracranial Human Glioblastoma," by John R. Ohlfest and colleagues is presented.

  • Cancer gene therapy update. Smith, J.A.; Goldspiel, B.R. // Journal of Oncology Pharmacy Practice;Mar1999, Vol. 5 Issue 1, p7 

    Objective. To provide an update about gene marking and gene therapy trials in cancer patients. Data Sources. A MEDLINE search using the term “gene therapy” was conducted for the period 1985 to 1998. The reference lists from retrieved articles were reviewed. Meeting abstracts from the...

  • Possibilities of Non-Viral Gene Transfer to Improve Cutaneous Wound Healing. Jeschke, M.G.; Herndon, D.N.; Baer, W.; Barrow, R.E.; Jauch, K.W. // Current Gene Therapy;Sep2001, Vol. 1 Issue 3, p267 

    Enhancement of dermal and epidermal regeneration represents a crucial goal for the treatment of acute, e.g. burn and trauma wounds, and chronic wounds, e.g. diabetic, autoimmune, arterial and venous wounds. Studies defining molecular mechanisms of the complex cascade of wound healing have shown...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics