TITLE

UCLA Scientists Image How Parkinson's Genes Misfire in Mice; May Help Identify Genes for Autism, Schizophrenia

PUB. DATE
May 2002
SOURCE
Ascribe Newswire: Health;5/29/2002, p10
SOURCE TYPE
Newswire
DOC. TYPE
Article
ABSTRACT
This article reports on the development, by UCLA scientists published in the June 2001 edition of the periodical "Genome Research," of a fast new way to image how thousands of genes misfire proteins in a mouse model of Parkinson's disease. The approach may provide a research blueprint for pinpointing abnormal brain regions linked to autism and schizophrenia. UCLA pharmacologist Desmond Smith used voxelation to compare gene expression in brains of mice. "This approach identifies which genes play a role in abnormal brain function and where they are located," said Smith.
ACCESSION #
11107816

 

Related Articles

  • Allelic variation of serotonin transporter expression is associated with depression in Parkinson's disease. Mössner, R.; Henneberg, A.; Schmitt, A.; Syagailo, Y.V.; Grässle, M.; Hennig, T.; Simantov, R.; Gerlach, M.; Riederer, P.; Lesch, K.P. // Molecular Psychiatry;2001, Vol. 6 Issue 3, p350 

    Idiopathic Parkinson's disease (PD) is a common neurodegenerative disorder with prominent motor symptoms. However, depression is common in PD, affecting about 40% of PD patients. Since there is extensive evidence of degeneration of serotonin (5HT) neurons and loss of the 5HT transporter (5HTT)...

  • Modeling protein loops with knowledge-based prediction of sequence-structure alignment. Hung-Pin Peng; An-Suei Yang // Bioinformatics;Nov2007, Vol. 23 Issue 21, p2836 

    Motivation: As protein structure database expands, protein loop modeling remains an important and yet challenging problem. Knowledge-based protein loop prediction methods have met with two challenges in methodology development: (1) loop boundaries in protein structures are frequently problematic...

  • Relationships Among Stop Codon Usage Bias, Its Context, Isochores, and Gene Expression Level in Various Eukaryotes. Jingchun Sun; Ming Chen; Jinlin Xu; Jianhua Luo; Manyuan Long // Journal of Molecular Evolution;Oct2005, Vol. 61 Issue 4, p437 

    It is well known that stop codons play a critical role in the process of protein synthesis. However, little effort has been made to investigate whether stop codon usage exhibits biases, such as widely seen for synonymous codon usage. Here we systematically investigate stop codon usage bias in...

  • Genome-Wide Association Study Heterogeneous Cohort Homogenization via Subject Weight Knock-Down. Valente, André X. C. N.; Zischkau, Joseph; Joo Heon Shin; Gao, Yuan; Sarkar, Abhijit // PLoS ONE;Oct2012, Vol. 7 Issue 10, Special section p1 

    Population structure can be a source of both false-positive and false-negative findings in a genome-wide association study. This article proposes an approach that helps to reduce the false-positives. It consists of homogenizing the diseased/healthy phenotype ratio across the cohort, by...

  • Enrichment of Conserved Synaptic Activity-Responsive Element in Neuronal Genes Predicts a Coordinated Response of MEF2, CREB and SRF. Rodríguez-Tornos, Fernanda M.; Aniceto, Iñigo San; Cubelos, Beatriz; Nieto, Marta // PLoS ONE;Jan2013, Vol. 8 Issue 1, Special section p1 

    A unique synaptic activity-responsive element (SARE) sequence, composed of the consensus binding sites for SRF, MEF2 and CREB, is necessary for control of transcriptional upregulation of the Arc gene in response to synaptic activity. We hypothesize that this sequence is a broad mechanism that...

  • Translation-State Analysis of Gene Expression in Mouse Brain After Focal Ischemia. John P. MacManus // Journal of Cerebral Blood Flow & Metabolism;Jun2004, Vol. 24 Issue 6, p657 

    SUMMARY:: Confounding any genome-scale analysis of gene expression after cerebral ischemia is massive suppression of protein synthesis. This inefficient translation questions the utility of examining profiles of total transcripts. Our approach to such postischemic gene profiling in the mouse by...

  • Spatial expression of the genome: the signal hypothesis at forty. Matlin, Karl S. // Nature Reviews Molecular Cell Biology;May2011, Vol. 12 Issue 5, p333 

    The signal hypothesis, formulated by Günter Blobel and David Sabatini in 1971, and elaborated by Blobel and his colleagues between 1975 and 1980, fundamentally expanded our view of cells by introducing the concept of topogenic signals. Cells were no longer just morphological entities with...

  • YY1 binds to α-synuclein 3′-flanking region SNP and stimulates antisense noncoding RNA expression. Mizuta, Ikuko; Takafuji, Kazuaki; Ando, Yuko; Satake, Wataru; Kanagawa, Motoi; Kobayashi, Kazuhiro; Nagamori, Shushi; Shinohara, Takayuki; Ito, Chiyomi; Yamamoto, Mitsutoshi; Hattori, Nobutaka; Murata, Miho; Kanai, Yoshikatsu; Murayama, Shigeo; Nakagawa, Masanori; Toda, Tatsushi // Journal of Human Genetics;Nov2013, Vol. 58 Issue 11, p711 

    α-synuclein (SNCA) is an established susceptibility gene for Parkinson's disease (PD), one of the most common human neurodegenerative disorders. Increased SNCA is considered to lead to PD and dementia with Lewy bodies. Four single-nucleotide polymorphisms (SNPs) in SNCA 3′ region were...

  • Comprehensive Assessment of Genetic Sequence Variants in the Antioxidant ‘Master Regulator’ Nrf2 in Idiopathic Parkinson’s Disease. Todorovic, Michael; Newman, Jeremy R. B.; Shan, Jianguo; Bentley, Steven; Wood, Stephen A.; Silburn, Peter A.; Mellick, George D. // PLoS ONE;May2015, Vol. 10 Issue 5, p1 

    Parkinson’s disease (PD) is a complex neurodegenerative disorder influenced by a combination of genetic and environmental factors. The molecular mechanisms that underlie PD are unknown; however, oxidative stress and impairment of antioxidant defence mechanisms have been implicated as...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics