Markers of atherosclerosis in relation to presence and progression of knee osteoarthritis: a population-based cohort study

Hoeven, Theun A.; Kavousi, Mary am; Ikram, Muhammed A.; van Meurs, Joyce B.; Bindels, Patrick J.; Hofman, Albert; Franco, Oscar H.; Bierma-Zeinstra, Sita M.
September 2015
Rheumatology;Sep2015, Vol. 54 Issue 9, p1692
Academic Journal
Objectives. To investigate the association between markers of atherosclerosis and the presence and progression of knee OA in a population-based cohort study. Methods. The study was performed within the framework of the prospective Rotterdam Study. Markers of atherosclerosis included coronary artery calcification (CAC) and plasma levels of CD40L, vascular cell adhesion molecule 1 (VCAM-1) and VEGF. CAC data were available for 1669 participants, and CD40L, VCAM-1 and VEGF data for 975. Radiographs of the knee were scored with the Kellgren and Lawrence score for OA at baseline and follow-up [average follow-up time 4.5 years (S.D. 0.5)]. We used multivariate logistic regression models with generalized estimated equations to calculate odds ratios (95% CIs) for the association of atherosclerosis markers with prevalence and progression of knee OA. Results. The mean age was 73.1 (S.D. 7.5) years. Within the study population, 18% had radiographic knee OA (11% of men and 23% of women). CAC and VEGF were not associated with prevalent knee OA. Only among women, CD40L [adjusted odds ratio 1.3 (1.1, 1.6)] and VCAM-1 [adjusted odds ratio 1.3 (1.1, 1.6)] were associated with prevalent knee OA. No associations with progression were found in women. In men, too few progressors were available to assess associations. Conclusion. In this population-based study, CAC and VEGF were not associated with the presence or progression of knee OA. Only among women, plasma levels of CD40L and VCAM-1 were higher in individuals with knee OA compared with those without knee OA. This might suggest an association between atherosclerosis and knee OA through low-grade systemic inflammation in women.


Related Articles

  • White Rice Intake Varies in Its Association with Metabolic Markers of Diabetes and Dyslipidemia Across Region among Chinese Adults. Dong, Fei; Howard, Annie-Green; Herring, Amy H.; Popkin, Barry M.; Gordon-Larsen, Penny // Annals of Nutrition & Metabolism;Aug2015, Vol. 66 Issue 4, p209 

    Background/Aims: There are inconsistent associations between white rice consumption and diabetes and dyslipidemia, perhaps due to the nature of samples studied and quality of diet data. Methods: Using regionally diverse data from adults enrolled in the China Health and Nutrition Survey (n =...

  • Physical Inactivity From Adolescence to Young Adulthood: The Relevance of Various Dimensions of Inequality in a Swedish Longitudinal Sample. Wells, Laura; Nermo, Magnus; Östberg, Viveca // Health Education & Behavior;Jun2017, Vol. 44 Issue 3, p376 

    As physical inactivity may track from adolescence to adulthood, it is important to identify social determinants of physical inactivity in early life. However, most studies have measured socioeconomic position as one dimension. We examine whether multiple dimensions of socioeconomic position, in...

  • The cross-sectional association between uric acid and atherosclerosis and the role of low-grade inflammation: the CODAM study. Wijnands, José M. A.; Boonen, Annelies; Dagnelie, Pieter C.; van Greevenbroek, Marleen M. J.; van der Kallen, Carla J. H.; Ferreira, Isabel; Schalkwijk, Casper G.; Feskens, Edith J. M.; Stehouwer, Coen D. A.; van der Linden, Sjef; Arts, Ilja C. W. // Rheumatology;Nov2014, Vol. 53 Issue 11, p2053 

    Objectives. The aims of this study were to investigate (i) associations between uric acid and prevalent cardiovascular disease (CVD), ankle–arm blood pressure index (AAIx) and carotid intima–media thickness (CIMT) in the total population and in predefined subgroups according to...

  • Individual site-specific bone mineral density gain in normocalcemic primary hyperparathyroidism. Koumakis, E.; Souberbielle, J.-C.; Payet, J.; Sarfati, E.; Borderie, D.; Kahan, A.; Cormier, C. // Osteoporosis International;Jul2014, Vol. 25 Issue 7, p1963 

    Summary: In this study, we show that successful parathyroidectomy is followed at 1 year by a significant individual bone mineral density (BMD) gain in nearly half of normocalcemic PHPT patients with reduced bone mass. Alkaline phosphatase levels above median were identified as an independent...

  • Plasma fatty acid lipidome is associated with cirrhosis prognosis and graft damage in liver transplantation. Ginanni Corradini, Stefano; Zerbinati, Chiara; Maldarelli, Federica; Palmaccio, Giuseppina; Parlati, Lucia; Giulia Bottaccioli, Anna; Molinaro, Antonio; Poli, Edoardo; Boaz, Mona; Serviddio, Gaetano; Mennini, Gianluca; Corsi, Alessandro; Bianco, Paolo; Rossi, Massimo; Iuliano, Luigi // American Journal of Clinical Nutrition;Aug2014, Vol. 100 Issue 2, p600 

    Background: Knowledge regarding the plasma fatty acid (FA) pattern in patients with liver cirrhosis is fragmentary. Objective: We evaluated plasma FA lipidome and its association with the prognosis of cirrhosis and severity of liver graft damage after transplantation. Design: In this...

  • Predicting Sjögren’s syndrome in patients with recent-onset SLE. Hernández-Molina, Gabriela; Zamora-Legoff, Tatiana; Romero-Díaz, Juanita; Nuñez-Alvarez, Carlos A.; Cárdenas-Velázquez, Francisco; Hernández-Hernández, Carlos; Calderillo, Maria Luisa; Marroquín, Martha; Recillas-Gispert, Claudia; Ávila-Casado, Carmen; Sánchez-Guerrero, Jorge // Rheumatology;Aug2013, Vol. 52 Issue 8, p1438 

    Objective. To determine the prevalence of SS in a cohort of recent-onset SLE patients and evaluate the clinical and immunological variables that may identify SLE patients prone to develop SS.Methods. A total of 103 patients participating in a prospective cohort of recent-onset SLE were assessed...

  • Inflammatory burden interacts with conventional cardiovascular risk factors for carotid plaque formation in rheumatoid arthritis. Churl Hyun Im; Na Ri Kim; Jong Wan Kang; Ji Hun Kim; Jin Young Kang; Gi Bum Bae; Eon Jeong Nam; Young Mo Kang // Rheumatology;May2015, Vol. 54 Issue 5, p808 

    Objective. Patients with RA have an increased risk of atherosclerosis and cardiovascular (CV) diseases compared with the general population. The aim of this study was to evaluate the role of inflammatory burden in the formation of carotid plaques in patients with RA. Methods. We performed...

  • Ultrasonographic predictors for clinical and radiological progression in knee osteoarthritis after 2 years of follow-up. Bevers, Karen; Vriezekolk, Johanna E.; Bijlsma, Johannes W. J.; van den Ende, Cornelia H. M.; den Broeder, Alfons A. // Rheumatology;Nov2015, Vol. 54 Issue 11, p2000 

    Objective. The aim of this study was to investigate the association between a set of US features and radiographic and clinical progression of knee OA after 2 years of follow-up. Methods. A total of 125 patients fulfilling ACR clinical criteria for knee OA underwent US examination of the most...

  • Prevalence and risk factors of arthritis in a middle-aged and older Chinese population: the China Health and Retirement Longitudinal Study. Changwei Li; Tingting Liu; Wenjie Sun; Lang Wu; Zhi-Yong Zou // Rheumatology;Apr2015, Vol. 54 Issue 4, p697 

    Objectives. The aims of this study were to estimate the prevalence of arthritis and to identify risk factors of arthritis in a middle-aged and older Chinese adult population. Methods. The China Health and Retirement Longitudinal Study (CHARLS) national survey data were used to estimate overall...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics