Crystallography of Membrane Proteins, Major Targets in Drug Design

J. Wouters
August 2003
Mini Reviews in Medicinal Chemistry;Aug2003, Vol. 3 Issue 5, p439
Academic Journal
Protein crystallography has the potential to accelerate drug discovery greatly. High-resolution structures of membrane proteins of pharmaceutical interest open new perspectives in drug design. Recent structural data obtained for cyclooxygenases, monoamine oxidase, squalene cyclase, rhodopsine, porins, aquaporins, and ABC transporters are presented and briefly discussed.


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