TITLE

Current overview on challenges in regenerative endodontics

AUTHOR(S)
Bansal, Ramta; Jain, Aditya; Mittal, Sunandan
PUB. DATE
January 2015
SOURCE
Journal of Conservative Dentistry;Jan/Feb2015, Vol. 18 Issue 1, p1
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Introduction: Regenerative endodontics provides hope of converting the non-vital tooth into vital once again. It focuses on substituting traumatized and pathological pulp with functional pulp tissue. Current regenerative procedures successfully produce root development but still fail to re-establish real pulp tissue and give unpredictable results. There are several drawbacks that need to be addressed to improve the quality and efficiency of the treatment. Aim: The aim of this review article is to discuss major priorities that ought to be dealt before applications of regenerative endodontics flourish the clinical practice. Materials and Methods: A web-based research on MEDLINE was done using filter terms Review, published in the last 10 years and Dental journals. Keywords used for research were "regenerative endodontics," "dental stem cells," "growth factor regeneration," "scaffolds," and "challenges in regeneration." This review article screened about 150 articles and then the relevant information was compiled. Results: Inspite of the impressive growth in regenerative endodontic field, there are certain loopholes in the existing treatment protocols that might sometimes result in undesired and unpredictable outcomes. Conclusion: Considerable research and development efforts are required to improve and update existing regenerative endodontic strategies to make it an effective, safe, and biological mode to save teeth.
ACCESSION #
100512427

 

Related Articles

  • Tissue engineering in endodontics. Saber, Shehab El-Din M. // Journal of Oral Science;Dec2009, Vol. 51 Issue 4, p495 

    Tissue engineering is the science of design and manufacture of new tissues to replace impaired or damaged ones. The key ingredients for tissue engineering are stem cells, the morphogens or growth factors that regulate their differentiation, and a scaffold of extracellular matrix that constitutes...

  • Scaffoldless Tissue-engineered Dental Pulp Cell Constructs for Endodontic Therapy. Syed-Picard, F.N.; Ray, H.L.; Kumta, P.N.; Sfeir, C. // Journal of Dental Research;Mar2014, Vol. 93 Issue 3, p250 

    A major cause of apical periodontitis after endodontic treatment is the bacterial infiltration which could have been challenged by the presence of a vital pulp. In this study, self-assembled, scaffoldless, three-dimensional (3D) tissues were engineered from dental pulp cells (DPCs) and assessed...

  • Tissue engineering and its application in endodontics: an overview. Loomba, Kapil; Bains, Rhythm; Bains, Vivek Kumar; Loomba, Anju; Nadig, Roopa R.; Shrivastava, Tarun V. // Endodontic Practice Today;Summer2012, Vol. 6 Issue 2, p105 

    Aim: To gain an overview of the basic concept of tissue engineering, which helps in understanding its potential application and scope in the field of clinical endodontic practice. Summary: The accepted use of regenerative therapy in the field of endodontics can be designed to restore and replace...

  • Regenerative endodontics. Simon, S.; Smith, A. J. // British Dental Journal;3/21/2014, Vol. 216 Issue 6, pE13 

    Background Significant advances in our understanding of the biological processes involved in tooth development and repair at the cellular and molecular levels have underpinned the newly emerging area of regenerative endodontics. Development of treatment protocols based on exploiting the natural...

  • Mineralization of Dense Collagen Hydrogel Scaffolds by Human Pulp Cells. Coyac, B.R.; Chicatun, F.; Hoac, B.; Nelea, V.; Chaussain, C.; Nazhat, S.N.; McKee, M.D. // Journal of Dental Research;Jul2013, Vol. 92 Issue 7, p648 

    While advances in biomineralization have been made in recent years, unanswered questions persist on bone- and tooth-cell differentiation, on outside-in signaling from the extracellular matrix, and on the link between protein expression and mineral deposition. In the present study, we validate...

  • Dentin-derived BMP-2 and Odontoblast Differentiation. Casagrande, L.; Demarco, F. F.; Zhang, Z.; Araujo, F. B.; Shi, S.; Nör, J. E. // Journal of Dental Research;Jun2010, Vol. 89 Issue 6, p603 

    It is known that stem cells from exfoliated deciduous teeth (SHED) can be induced to differentiate into odontoblasts. However, the nature of dentin-derived morphogenic signals required for dental pulp stem cell differentiation remains unclear. The hypothesis underlying this work is that...

  • Tissue Engineering for Bone Production- Stem Cells, Gene Therapy and Scaffolds. Khaled, E.G.; Saleh, M.; Hindocha, S.; Griffin, M.; Khan, Wasim S. // Open Orthopaedics Journal;2011 Special Issue 002, Vol. 5 Issue S2, p289 

    A bone graft has been the gold standard treatment for repairing bone defects. However, due to bone grafts associated donor site morbidity several alternative bone substitutes options have been made available but with their added expense and limited osteoinductive properties they are not ideal....

  • A Novel Albumin-Based Tissue Scaffold for Autogenic Tissue Engineering Applications. Pei-Shan Li; I.-Liang Lee; Wei-Lin Yu; Jui-Sheng Sun; Wann-Neng Jane; Hsin-Hsin Shen // Scientific Reports;7/18/2014, p1 

    Tissue scaffolds provide a framework for living tissue regeneration. However, traditional tissue scaffolds are exogenous, composed of metals, ceramics, polymers, and animal tissues, and have a defined biocompatibility and application. This study presents a new method for obtaining a tissue...

  • Recent Advances in Hydroxyapatite Scaffolds Containing Mesenchymal Stem Cells. Michel, John; Penna, Matthew; Kochen, Juan; Cheung, Herman // Stem Cells International;5/28/2015, Vol. 2015, p1 

    Modern day tissue engineering and cellular therapies have gravitated toward using stem cells with scaffolds as a dynamic modality to aid in differentiation and tissue regeneration. Mesenchymal stem cells (MSCs) are one of the most studied stem cells used in combination with scaffolds. These...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics