TITLE

Recent Advances in Toxoplasma gondii Immunotherapeutics

AUTHOR(S)
Swee-Yin Lim, Sherene; Othman, Rofina Yasmin
PUB. DATE
December 2014
SOURCE
Korean Journal of Parasitology;Dec2014, Vol. 52 Issue 6, p581
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Toxoplasmosis is an opportunistic infection caused by the protozoan parasite Toxoplasma gondii. T. gondii is widespread globally and causes severe diseases in individuals with impaired immune defences as well as congenitally infected infants. The high prevalence rate in some parts of the world such as South America and Africa, coupled with the current drug treatments that trigger hypersensitivity reactions, makes the development of immunotherapeutics intervention a highly important research priority. Immunotherapeutics strategies could either be a vaccine which would confer a pre-emptive immunity to infection, or passive immunization in cases of disease recrudescence or recurrent clinical diseases. As the severity of clinical manifestations is often greater in developing nations, the development of well-tolerated and safe immunotherapeutics becomes not only a scientific pursuit, but a humanitarian enterprise. In the last few years, much progress has been made in vaccine research with new antigens, novel adjuvants, and innovative vaccine delivery such as nanoparticles and antigen encapsulations. A literature search over the past 5 years showed that most experimental studies were focused on DNA vaccination at 52%, followed by protein vaccination which formed 36% of the studies, live attenuated vaccinations at 9%, and heterologous vaccination at 3%; while there were few on passive immunization. Recent progress in studies on vaccination, passive immunization, as well as insights gained from these immunotherapeutics is highlighted in this review.
ACCESSION #
100212044

 

Related Articles

  • Fatal Attraction. Holden, Karina; Hickey, Georgina // Nature Australia;Summer2001-2002, Vol. 27 Issue 3, p8 

    Reveals the findings of a research that had examined the behavioral differences between healthy laboratory rats and those infected with Toxoplasma gondii, a protozoan that is capable of infecting all mammals whose host is the cat. How a parasite turns a scared rat into a cat-fighting rat.

  • Analysis of Toxoplasma gondii surface antigen 2 gene (SAG2). Relevance of genotype I in clinical toxoplasmosis. Sabaj, Valeria; Galindo, Mario; Silva, Daniela; Sandoval, Lea; Rodríguez, Juan // Molecular Biology Reports;Jul2010, Vol. 37 Issue 6, p2927 

    Toxoplasma gondii is one of the most successful protozoan parasites given its ability to manipulate the immune system and establish a chronic infection. It is a parasite with a significant impact on human health, mainly in immunocompromised patients. In Europe and North America, only a few...

  • Secondary Mutations Correct Fitness Defects in Toxoplasma gondii With Dinitroaniline Resistance Mutations. Ma, Christopher; Tran, Johnson; Li, Catherine; Ganesan, Lakshmi; Wood, David; Morrissette, Naomi // Genetics;Oct2008, Vol. 180 Issue 2, p845 

    Dinitroanilines (oryzalin, trifluralin, ethafluralin) disrupt microtubules in protozoa but not in vertebrate cells, causing selective death of intracellular Toxoplasma gondii parasites without affecting host cells. Parasites containing α1-tubulin point mutations are dinitroaniline resistant...

  • A SURVEY OF NEOSPORA CANINUM AND TOXOPLASMA GONDII INFECTION IN URBAN RODENTS FROM BRAZIL. Muradian, Vanessa; Ferreira, Leandra Ribeiro; Lopes, Estela Gallucci; de Oliveira Esmerini, Patricia; de Jesus Pena, Hilda Fátima; Soares, Rodrigo Martins; Gennari, Solange Maria // Journal of Parasitology;Feb2012, Vol. 98 Issue 1, p128 

    Toxoplasma gondii is a protozoan parasite that infects humans and other warm-blooded animals; it uses feral and domestic cats as the definitive hosts. Neospora caninum is a protozoan parasite of animals whose life cycle is very similar to T. gondii but uses canids as definitive hosts. Small...

  • Microbiology: Protein behind protozoan power.  // Nature;6/1/2011, Vol. 474 Issue 7349, p9 

    The article reports that a study by David Sibley and colleagues of Washington University in Saint Louis, Missouri revealed that the Rhoptry protein 5 (ROP5) may be the protein that regulate the virulence of the protozoa, Toxoplasma gondii.

  • A NEW ALTERNATIVE IN VITRO METHOD FOR QUANTIFICATION OF TOXOPLASMA GONDII INFECTIVITY. Useo, Romain; Husson, Florence; De Coninck, Joelle; Khaldi, Samira; Gervais, Patrick // Journal of Parasitology;Apr2012, Vol. 98 Issue 2, p299 

    An in vitro method to determine the infectious potency of an unknown suspension of the protozoan parasite Toxoplasma gondii based on kinetics of host cells lysis was developed. Mic1-3KO a mutant strain of T. gondii RH tachyzoites was inoculated in 25-cm² flasks containing a 90% confluent...

  • Survey of Toxoplasma gondii in Taipei: Livestock Meats, Internal Organs, Cat and Dog Sera. Ying-Bin Fuh; Chen-Si Lin; Liao, Albert Taiching; Yun-Ming Pong; Meng-Chih Tung; Chang-Young Fei; Dah-Sheng Lin // Thai Journal of Veterinary Medicine;Mar2013, Vol. 43 Issue 1, p15 

    Toxoplasma gondii (T. gondii) is an important food-borne zoonotic protozoa. Infection occurs when humans and warm-blooded animals consume raw or lightly cooked cysts containing meat or sporulated oocysts contaminated food. T. gondii infection has been observed in food animals in many countries...

  • Toxoplasma Effector MAF1 Mediates Recruitment of Host Mitochondria and Impacts the Host Response. Pernas, Lena; Adomako-Ankomah, Yaw; Shastri, Anjali J.; Ewald, Sarah E.; Treeck, Moritz; Boyle, Jon P.; Boothroyd, John C. // PLoS Biology;Apr2014, Vol. 12 Issue 4, p1 

    : The intracellular human protozoan parasite Toxoplasma gondii uses a novel secreted protein to recruit host mitochondria and alter the host's response to infection.

  • Host Cell Egress and Invasion Induce Marked Relocations of Glycolytic Enzymes in Toxoplasma gondii Tachyzoites. Pomel, Sebastien; Luk, Flora C. Y.; Beckers, Con J. M. // PLoS Pathogens;Oct2008, Vol. 4 Issue 10, p1 

    Apicomplexan parasites are dependent on an F-actin and myosin-based motility system for their invasion into and escape from animal host cells, as well as for their general motility. In Toxoplasma gondii and Plasmodium species, the actin filaments and myosin motor required for this process are...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics